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| Human cd71 (aa 569 – 760) |
| CD71 Swiss Prot | | P02786 |
| CD71 Protein names | | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)] |
| CD71 Gene names | | TFRC |
| Organism | | Human |
| CD71 Entry name | | TFR1_HUMAN |
| CD71 Codon optimized cDNA Clone |
| CD71 cDNA Cat | | RPV0804 |
| cDNA Tag | | cDNA CD71 contains A 6x histidine tag |
| Condon optimized CD71 cDNA Formulation | | Liquid |
| Condon optimized CD71 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD71 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD71 Protein |
| Recombinant CD71 Protein Cat | | PV0804 |
| CD71 Protein Source | | Recombinant protein |
| Recombinant CD71 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD71 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD71 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD71 contains A 6x histidine tag |
| Recombinant CD71 Protein Formulation | | Liquid |
| Recombinant CD71 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD71 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD71 SUBUNIT | | SUBUNIT: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC. |
| CD71 Subcellular locations | | SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; SUBCELLULAR LOCATION: Transferrin receptor protein 1, serum form: Secreted. |
| CD71 FUNCTION According to UniProtKB Swiss Prot | | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary |
| | hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. |
| CD71 Sequence databases | | EMBL | DDBJ | GenBank |
| CD71 3D structure databases | | ModBase |
| CD71 Protein protein interaction databases | | STRING |
| CD71 Proteomic databases | | PRIDE |
| CD71 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD71 Organism specific databases | | CTD | MGI |
| CD71 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD71 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD71 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
