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| Human cd74 (aa 73 – 296) |
| CD74 Swiss Prot | | P04233 |
| CD74 Protein names | | HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD antigen CD74) |
| CD74 Gene names | | CD74 DHLAG |
| Organism | | Human |
| CD74 Entry name | | HG2A_HUMAN |
| CD74 Codon optimized cDNA Clone |
| CD74 cDNA Cat | | RPV0813 |
| cDNA Tag | | cDNA CD74 contains A 6x histidine tag |
| Condon optimized CD74 cDNA Formulation | | Liquid |
| Condon optimized CD74 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD74 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD74 Protein |
| Recombinant CD74 Protein Cat | | PV0813 |
| CD74 Protein Source | | Recombinant protein |
| Recombinant CD74 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD74 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD74 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD74 contains A 6x histidine tag |
| Recombinant CD74 Protein Formulation | | Liquid |
| Recombinant CD74 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD74 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD74 SUBUNIT | | SUBUNIT: Homotrimer. In the endoplasmic reticulum (ER) it forms an heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II- |
| | associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic |
| | peptides to the MHC class II molecules. |
| CD74 Subcellular locations | | SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein (Potential). Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane. |
| CD74 FUNCTION According to UniProtKB Swiss Prot | | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. |
| CD74 Sequence databases | | EMBL | DDBJ | GenBank |
| CD74 3D structure databases | | ModBase |
| CD74 Protein protein interaction databases | | STRING |
| CD74 Proteomic databases | | PRIDE |
| CD74 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD74 Organism specific databases | | CTD | MGI |
| CD74 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD74 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD74 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
