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| Human cd79a (aa 33 – 143) |
| CD79a Swiss Prot | | P11912 |
| CD79a Protein names | | B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a) |
| CD79a Gene names | | CD79A IGA MB1 |
| Organism | | Human |
| CD79a Entry name | | CD79A_HUMAN |
| CD79a Codon optimized cDNA Clone |
| CD79a cDNA Cat | | RPV0819 |
| cDNA Tag | | cDNA CD79a contains A 6x histidine tag |
| Condon optimized CD79a cDNA Formulation | | Liquid |
| Condon optimized CD79a cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD79a cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD79a Protein |
| Recombinant CD79a Protein Cat | | PV0819 |
| CD79a Protein Source | | Recombinant protein |
| Recombinant CD79a Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD79a Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD79a Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD79a contains A 6x histidine tag |
| Recombinant CD79a Protein Formulation | | Liquid |
| Recombinant CD79a Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD79a Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD79a SUBUNIT | | SUBUNIT: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-210, with the SH2 |
| | domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing |
| | their activity (By similarity). |
| CD79a Subcellular locations | | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts (By similarity). |
| CD79a FUNCTION According to UniProtKB Swiss Prot | | Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to |
| | phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B cells. |
| CD79a Sequence databases | | EMBL | DDBJ | GenBank |
| CD79a 3D structure databases | | ModBase |
| CD79a Protein protein interaction databases | | STRING |
| CD79a Proteomic databases | | PRIDE |
| CD79a Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD79a Organism specific databases | | CTD | MGI |
| CD79a Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD79a Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD79a Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
