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| Human cd91 (aa 20 – 420) |
| CD91 Swiss Prot | | Q07954 |
| CD91 Protein names | | Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] |
| CD91 Gene names | | LRP1 A2MR APR |
| Organism | | Human |
| CD91 Entry name | | LRP1_HUMAN |
| CD91 Codon optimized cDNA Clone |
| CD91 cDNA Cat | | RPV0877 |
| cDNA Tag | | cDNA CD91 contains A 6x histidine tag |
| Condon optimized CD91 cDNA Formulation | | Liquid |
| Condon optimized CD91 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD91 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD91 Protein |
| Recombinant CD91 Protein Cat | | PV0877 |
| CD91 Protein Source | | Recombinant protein |
| Recombinant CD91 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD91 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD91 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD91 contains A 6x histidine tag |
| Recombinant CD91 Protein Formulation | | Liquid |
| Recombinant CD91 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD91 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD91 SUBUNIT | | SUBUNIT: Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa amino-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1. Interacts with bacterial exotoxins. |
| CD91 Subcellular locations | | SUBCELLULAR LOCATION: Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit. ; SUBCELLULAR LOCATION: Low-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit. ; SUBCELLULAR LOCATION: Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After |
| | cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. |
| CD91 FUNCTION According to UniProtKB Swiss Prot | | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal |
| | calcium signaling as well as neurotransmission.; Functions as a receptor for Pseudomonas aeruginosa exotoxin A. |
| CD91 Sequence databases | | EMBL | DDBJ | GenBank |
| CD91 3D structure databases | | ModBase |
| CD91 Protein protein interaction databases | | STRING |
| CD91 Proteomic databases | | PRIDE |
| CD91 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD91 Organism specific databases | | CTD | MGI |
| CD91 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD91 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD91 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
