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| Rat cd98 (aa 99 – 527) |
| CD98 Swiss Prot | | Q794F9 |
| CD98 Protein names | | 4F2 cell-surface antigen heavy chain (4F2hc) (CD antigen CD98) |
| CD98 Gene names | | Slc3a2 |
| Organism | | Rat |
| CD98 Entry name | | 4F2_RAT |
| CD98 Codon optimized cDNA Clone |
| CD98 cDNA Cat | | RPV0897 |
| cDNA Tag | | cDNA CD98 contains A 6x histidine tag |
| Condon optimized CD98 cDNA Formulation | | Liquid |
| Condon optimized CD98 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD98 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD98 Protein |
| Recombinant CD98 Protein Cat | | PV0897 |
| CD98 Protein Source | | Recombinant protein |
| Recombinant CD98 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD98 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD98 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD98 contains A 6x histidine tag |
| Recombinant CD98 Protein Formulation | | Liquid |
| Recombinant CD98 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD98 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD98 SUBUNIT | | SUBUNIT: Disulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5, SLC7A6, SLCA7A7, SLC7A8, SLC7A10 or SLCA7A11). Colocalizes with cadherins (By similarity). Interacts with FAM57A/CT120 and ICAM1 (By similarity). Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1 (By similarity). |
| CD98 Subcellular locations | | SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type II membrane protein. Melanosome (By similarity). Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). Localized to the plasma membrane when associated with SLC7A5 or SLC7A8 (By similarity). Localized to the placental apical membrane (By similarity). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the |
| | basolateral membrane of kidney proximal tubules and small intestine epithelia (By similarity). Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. |
| CD98 FUNCTION According to UniProtKB Swiss Prot | | Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for |
| | extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also |
| | involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) |
| | when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight |
| | nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular |
| | signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. |
| CD98 Sequence databases | | EMBL | DDBJ | GenBank |
| CD98 3D structure databases | | ModBase |
| CD98 Protein protein interaction databases | | STRING |
| CD98 Proteomic databases | | PRIDE |
| CD98 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD98 Organism specific databases | | CTD | MGI |
| CD98 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD98 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD98 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
