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| Mouse cd124 (aa 26 – 233) |
| CD124 Swiss Prot | | P16382 |
| CD124 Protein names | | Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)] |
| CD124 Gene names | | Il4r Il4ra |
| Organism | | Mouse |
| CD124 Entry name | | IL4RA_MOUSE |
| CD124 Codon optimized cDNA Clone |
| CD124 cDNA Cat | | RPV0096 |
| cDNA Tag | | cDNA CD124 contains A 6x histidine tag |
| Condon optimized CD124 cDNA Formulation | | Liquid |
| Condon optimized CD124 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD124 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD124 Protein |
| Recombinant CD124 Protein Cat | | PV0096 |
| CD124 Protein Source | | Recombinant protein |
| Recombinant CD124 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD124 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD124 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD124 contains A 6x histidine tag |
| Recombinant CD124 Protein Formulation | | Liquid |
| Recombinant CD124 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD124 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD124 SUBUNIT | | SUBUNIT: The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (By similarity). |
| | Interacts with JAK1 through a Box 1-containing region. In Th1 cells, binds the N-terminal 50 amino acids of SOCS5, which inhibits JAK1 interaction, STAT6 activation and Th2 cell differentiation. SOCS5 interaction is independent of tyrosine |
| | phosphorylation. |
| CD124 Subcellular locations | | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. ; SUBCELLULAR LOCATION: Isoform 2: Secreted. |
| CD124 FUNCTION According to UniProtKB Swiss Prot | | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. |
| CD124 Sequence databases | | EMBL | DDBJ | GenBank |
| CD124 3D structure databases | | ModBase |
| CD124 Protein protein interaction databases | | STRING |
| CD124 Proteomic databases | | PRIDE |
| CD124 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD124 Organism specific databases | | CTD | MGI |
| CD124 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD124 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD124 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
