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MOUSE Cadm1 (aa 43-456 )
Cadm1 Swiss-Prot #
Q8R5M8
Cadm1 Protein names
Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like

protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell

adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
Cadm1 Gene names
Cadm1 Igsf4 Necl2 Ra175 Syncam SynCam1 Tslc1
Organism
Mus musculus (Mouse)
Cadm1 Entry name
CADM1_MOUSE

Cadm1 Codon-optimized cDNA Clone
Cadm1 CDNA Cat#
RPY1082
Tag
cDNA Cadm1 contains A 6x histidine tag
Condon optimized Cadm1 cDNA Formulation
Liquid
Condon optimized Cadm1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Cadm1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cadm1 Protein
Recombinant Cadm1 Protein Cat#
PY1082
Cadm1 Protein Source
Recombinant protein
Recombinant Cadm1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Cadm1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Cadm1 Protein Activity
N/A
Tag
Recombinant Cadm1 contains A 6x histidine tag
Recombinant Cadm1 protein Formulation
Liquid
Recombinant Cadm1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
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Cadm1 Protein family
Nectin family
Cadm1 Subcellular locations
Cell membrane; Single-pass type I membrane protein.
Cadm1 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent

manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a

Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung

cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell

cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as

well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May

contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast

cells, may mediate attachment to and promote communication with nerves. CADM1,

together with MITF, is essential for development and survival of mast cells in vivo.

May act as a synaptic cell adhesion molecule that drives synapse assembly. May be

involved in neuronal migration, axon growth, pathfinding, and fasciculation on the

axons of differentiating neurons. May play diverse roles in the spermatogenesis

including in the adhesion of spermatocytes and spermatids to Sertoli cells and for

their normal differentiation into mature spermatozoa.
Cadm1 Sequence databases
EMBL DDBJ GenBank
Cadm1 3D structure databases
ModBase
Cadm1 Protein-protein interaction databases
STRING
Cadm1 Proteomic databases
PRIDE
Cadm1 Genome annotation databases
Ensembl GeneID KEGG UCSC
Cadm1 Organism-specific databases
CTD MGI
Cadm1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Cadm1 Gene expression databases
Bgee ArrayExpress Genevestigator
Cadm1 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.