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RAT Abi1 (aa 13-476 )
Abi1 Swiss-Prot #
Q9QZM5
Abi1 Protein names
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Eps8 SH3 domain-binding protein) (Eps8-

binding protein) (e3B1)
Abi1 Gene names
Abi1
Organism
Rattus norvegicus (Rat)
Abi1 Entry name
ABI1_RAT

Abi1 Codon-optimized cDNA Clone
Abi1 CDNA Cat#
RPY1146
Tag
cDNA Abi1 contains A 6x histidine tag
Condon optimized Abi1 cDNA Formulation
Liquid
Condon optimized Abi1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Abi1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Abi1 Protein
Recombinant Abi1 Protein Cat#
PY1146
Abi1 Protein Source
Recombinant protein
Recombinant Abi1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Abi1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Abi1 Protein Activity
N/A
Tag
Recombinant Abi1 contains A 6x histidine tag
Recombinant Abi1 protein Formulation
Liquid
Recombinant Abi1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Abi1 Protein or cDNA
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Abi1 Protein family
ABI family
Abi1 Subcellular locations
Cytoplasm. Nucleus. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection >

growth cone. Cell junction > synapse > synaptosome. Cytoplasm > cytoskeleton.
Abi1 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: May act in negative regulation of cell growth and transformation by

interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in

regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal

reorganization and EGFR signaling. Together with EPS8 participates in

transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8

and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity

and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-

mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there

seems to regulate WASF1 protein level (By similarity).
Abi1 Sequence databases
EMBL DDBJ GenBank
Abi1 3D structure databases
ModBase
Abi1 Protein-protein interaction databases
STRING
Abi1 Proteomic databases
PRIDE
Abi1 Genome annotation databases
Ensembl GeneID KEGG UCSC
Abi1 Organism-specific databases
CTD MGI
Abi1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Abi1 Gene expression databases
Bgee ArrayExpress Genevestigator
Abi1 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.