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RAT Podxl (aa 24-485 )
Podxl Swiss-Prot #
Q9WTQ2
Podxl Protein names
Podocalyxin (Podocalyxin-like protein 1) (PC) (PCLP-1)
Podxl Gene names
Podxl Pclp1
Organism
Rattus norvegicus (Rat)
Podxl Entry name
PODXL_RAT

Podxl Codon-optimized cDNA Clone
Podxl CDNA Cat#
RPY1173
Tag
cDNA Podxl contains A 6x histidine tag
Condon optimized Podxl cDNA Formulation
Liquid
Condon optimized Podxl cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Podxl cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag.

2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Podxl Protein
Recombinant Podxl Protein Cat#
PY1173
Podxl Protein Source
Recombinant protein
Recombinant Podxl Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Podxl Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Podxl Protein Activity
N/A
Tag
Recombinant Podxl contains A 6x histidine tag
Recombinant Podxl protein Formulation
Liquid
Recombinant Podxl protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
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Podxl Protein family
Podocalyxin family
Podxl Subcellular locations
Apical cell membrane. Cell projection > microvillus. Membrane raft. Cell projection > lamellipodium.

Cell projection > filopodium. Cell projection > ruffle. Membrane; Single-pass type I membrane protein.
Podxl FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Involved in the regulation of both adhesion and cell morphology and

cancer progression. Function as an anti-adhesive molecule that maintains an open

filtration pathway between neighboring foot processes in the podocyte by charge

repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to

immobilized ligands, increasing the rate of migration and cell-cell contacts in an

integrin-dependent manner. Induces the formation of apical actin-dependent

microvilli. Involved in the formation of a preapical plasma membrane subdomain to

set up inital epithelial polarization and the apical lumen formation during renal

tubulogenesis. Plays a role in cancer development and aggressiveness by inducing

cell migration and invasion through its interaction with the actin-binding protein

EZR. Affects EZR-dependent signaling events, leading to increased activities of

the MAPK and PI3K pathways in cancer cells.
Podxl Sequence databases
EMBL DDBJ GenBank
Podxl 3D structure databases
ModBase
Podxl Protein-protein interaction databases
STRING
Podxl Proteomic databases
PRIDE
Podxl Genome annotation databases
Ensembl GeneID KEGG UCSC
Podxl Organism-specific databases
CTD MGI
Podxl Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Podxl Gene expression databases
Bgee ArrayExpress Genevestigator
Podxl Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.