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HUMAN DYNLL1 (aa 1-89 )
DYNLL1 Swiss-Prot #
P63167
DYNLL1 Protein names
Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-

type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)
DYNLL1 Gene names
DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1
Organism
Homo sapiens (Human)
DYNLL1 Entry name
DYL1_HUMAN

DYNLL1 Codon-optimized cDNA Clone
DYNLL1 CDNA Cat#
RPY0012
Tag
cDNA DYNLL1 contains A 6x histidine tag
Condon optimized DYNLL1 cDNA Formulation
Liquid
Condon optimized DYNLL1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized DYNLL1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant DYNLL1 Protein
Recombinant DYNLL1 Protein Cat#
PY0012
DYNLL1 Protein Source
Recombinant protein
Recombinant DYNLL1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant DYNLL1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant DYNLL1 Protein Activity
N/A
Tag
Recombinant DYNLL1 contains A 6x histidine tag
Condon optimized DYNLL1 cDNA Formulation
Liquid
Condon optimized DYNLL1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant DYNLL1 Protein or cDNA
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DYNLL1 Protein family
Dynein light chain family
DYNLL1 Subcellular locations
Cytoplasm > cytoskeleton. Nucleus. Mitochondrion.
DYNLL1 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Acts as one of several non-catalytic accessory components of the

cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to

cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1

acts as a motor for the intracellular retrograde motility of vesicles and organelles

along microtubules. May play a role in changing or maintaining the spatial

distribution of cytoskeletal structures.; FUNCTION: Binds and inhibits the catalytic

activity of neuronal nitric oxide synthase.; FUNCTION: Promotes transactivation

functions of ESR1 and plays a role in the nuclear localization of ESR1.;

FUNCTION: Regulates apoptotic activities of BCL2L11 by sequestering it to

microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates

from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2

thus neutralizing its antiapoptotic activity.
DYNLL1 Sequence databases
EMBL DDBJ GenBank
DYNLL1 3D structure databases
ModBase
DYNLL1 Protein-protein interaction databases
STRING
DYNLL1 Proteomic databases
PRIDE
DYNLL1 Genome annotation databases
Ensembl GeneID KEGG UCSC
DYNLL1 Organism-specific databases
CTD MGI
DYNLL1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
DYNLL1 Gene expression databases
Bgee ArrayExpress Genevestigator
DYNLL1 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.