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HUMAN TRAF2 (aa 1-501 )
TRAF2 Swiss-Prot #
Q12933
TRAF2 Protein names
TNF receptor-associated factor 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF2) (Tumor

necrosis factor type 2 receptor-associated protein 3)
TRAF2 Gene names
TRAF2 TRAP3
Organism
Homo sapiens (Human)
TRAF2 Entry name
TRAF2_HUMAN

TRAF2 Codon-optimized cDNA Clone
TRAF2 CDNA Cat#
RPY1226
Tag
cDNA TRAF2 contains A 6x histidine tag
Condon optimized TRAF2 cDNA Formulation
Liquid
Condon optimized TRAF2 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized TRAF2 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant TRAF2 Protein
Recombinant TRAF2 Protein Cat#
PY1226
TRAF2 Protein Source
Recombinant protein
Recombinant TRAF2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant TRAF2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant TRAF2 Protein Activity
N/A
Tag
Recombinant TRAF2 contains A 6x histidine tag
Recombinant TRAF2 protein Formulation
Liquid
Recombinant TRAF2 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant TRAF2 Protein or cDNA
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TRAF2 Protein family
TNF receptor-associated factor family, A subfamily
TRAF2 Subcellular locations
Cytoplasm.
TRAF2 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Regulates activation of NF-kappa-B and JNK and plays a central role

in the regulation of cell survival and apoptosis. Required for normal antibody isotype

switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes

'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and

TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase

complexes, where it promotes the ubiquitination of target proteins by bringing them

into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein

levels by inhibiting their autoubiquitination and subsequent degradation; this does

not depend on the TRAF2 RING-type zinc finger domain.
TRAF2 Sequence databases
EMBL DDBJ GenBank
TRAF2 3D structure databases
ModBase
TRAF2 Protein-protein interaction databases
STRING
TRAF2 Proteomic databases
PRIDE
TRAF2 Genome annotation databases
Ensembl GeneID KEGG UCSC
TRAF2 Organism-specific databases
CTD MGI
TRAF2 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
TRAF2 Gene expression databases
Bgee ArrayExpress Genevestigator
TRAF2 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.