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HUMAN PRPF19 (aa 10-504 )
PRPF19 Swiss-Prot #
Q9UMS4
PRPF19 Protein names
Pre-mRNA-processing factor 19 (Nuclear matrix protein 200) (PRP19/PSO4 homolog)

(hPso4) (Senescence evasion factor)
PRPF19 Gene names
PRPF19 NMP200 PRP19 SNEV
Organism
Homo sapiens (Human)
PRPF19 Entry name
PRP19_HUMAN

PRPF19 Codon-optimized cDNA Clone
PRPF19 CDNA Cat#
RPY1240
Tag
cDNA PRPF19 contains A 6x histidine tag
Condon optimized PRPF19 cDNA Formulation
Liquid
Condon optimized PRPF19 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized PRPF19 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant PRPF19 Protein
Recombinant PRPF19 Protein Cat#
PY1240
PRPF19 Protein Source
Recombinant protein
Recombinant PRPF19 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant PRPF19 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant PRPF19 Protein Activity
N/A
Tag
Recombinant PRPF19 contains A 6x histidine tag
Recombinant PRPF19 protein Formulation
Liquid
Recombinant PRPF19 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant PRPF19 Protein or cDNA
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PRPF19 Protein family
WD repeat PRP19 family
PRPF19 Subcellular locations
Nucleus. Nucleus > nucleoplasm. Cytoplasm > cytoskeleton > spindle.
PRPF19 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Plays a role in DNA double-strand break (DSB) repair and pre-

mRNA splicing reaction. Binds double-stranded DNA in a sequence-nonspecific

manner. Acts as a structural component of the nuclear framework. May also serve

as a support for spliceosome binding and activity. Essential for spliceosome

assembly in a oligomerization-dependent manner and might also be important for

spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is

required in the DNA interstrand cross-links (ICLs) repair process. Overexpression

of PRPF19 might extend the cellular life span by increasing the resistance to

stress or by improving the DNA repair capacity of the cells.
PRPF19 Sequence databases
EMBL DDBJ GenBank
PRPF19 3D structure databases
ModBase
PRPF19 Protein-protein interaction databases
STRING
PRPF19 Proteomic databases
PRIDE
PRPF19 Genome annotation databases
Ensembl GeneID KEGG UCSC
PRPF19 Organism-specific databases
CTD MGI
PRPF19 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
PRPF19 Gene expression databases
Bgee ArrayExpress Genevestigator
PRPF19 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.