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MOUSE Sgol1 (aa 1-517 )
Sgol1 Swiss-Prot #
Q9CXH7
Sgol1 Protein names
Shugoshin-like 1
Sgol1 Gene names
Sgol1 Sgo1
Organism
Mus musculus (Mouse)
Sgol1 Entry name
SGOL1_MOUSE

Sgol1 Codon-optimized cDNA Clone
Sgol1 CDNA Cat#
RPY1261
Tag
cDNA Sgol1 contains A 6x histidine tag
Condon optimized Sgol1 cDNA Formulation
Liquid
Condon optimized Sgol1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Sgol1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag.

2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Sgol1 Protein
Recombinant Sgol1 Protein Cat#
PY1261
Sgol1 Protein Source
Recombinant protein
Recombinant Sgol1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Sgol1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Sgol1 Protein Activity
N/A
Tag
Recombinant Sgol1 contains A 6x histidine tag
Recombinant Sgol1 protein Formulation
Liquid
Recombinant Sgol1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Sgol1 Protein or cDNA
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Sgol1 Protein family
Shugoshin family
Sgol1 Subcellular locations
Nucleus. Chromosome > centromere. Chromosome > centromere > kinetochore. Cytoplasm >

cytoskeleton > spindle pole. Cytoplasm > cytoskeleton > centrosome.
Sgol1 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Plays a central role in chromosome cohesion during mitosis by

preventing premature dissociation of cohesin complex from centromeres after

prophase, when most of cohesin complex dissociates from chromosomes arms.

May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at

the centromere, ensuring cohesin persistence at centromere until cohesin cleavage

by ESPL1/separase at anaphase. Essential for proper chromosome segregation

during mitosis and this function requires interaction with PPP2R1A. Its

phosphorylated form is necessary for chromosome congression and for the proper

attachment of spindle microtubule to the kinetochore. Necessary for kinetochore

localization of PLK1 and CENPF. May play a role in the tension sensing

mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore

affinity.
Sgol1 Sequence databases
EMBL DDBJ GenBank
Sgol1 3D structure databases
ModBase
Sgol1 Protein-protein interaction databases
STRING
Sgol1 Proteomic databases
PRIDE
Sgol1 Genome annotation databases
Ensembl GeneID KEGG UCSC
Sgol1 Organism-specific databases
CTD MGI
Sgol1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Sgol1 Gene expression databases
Bgee ArrayExpress Genevestigator
Sgol1 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.