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HUMAN PDZK1 (aa 1-519 )
PDZK1 Swiss-Prot #
Q5T2W1
PDZK1 Protein names
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of

70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-

associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen

exchanger regulatory factor 3)
PDZK1 Gene names
PDZK1 CAP70 NHERF3 PDZD1
Organism
Homo sapiens (Human)
PDZK1 Entry name
NHRF3_HUMAN

PDZK1 Codon-optimized cDNA Clone
PDZK1 CDNA Cat#
RPY1264
Tag
cDNA PDZK1 contains A 6x histidine tag
Condon optimized PDZK1 cDNA Formulation
Liquid
Condon optimized PDZK1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized PDZK1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant PDZK1 Protein
Recombinant PDZK1 Protein Cat#
PY1264
PDZK1 Protein Source
Recombinant protein
Recombinant PDZK1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant PDZK1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant PDZK1 Protein Activity
N/A
Tag
Recombinant PDZK1 contains A 6x histidine tag
Recombinant PDZK1 protein Formulation
Liquid
Recombinant PDZK1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
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PDZK1 Protein family
NHER family
PDZK1 Subcellular locations
Cytoplasm. Membrane; Peripheral membrane protein.
PDZK1 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: A scaffold protein that connects plasma membrane proteins and

regulatory components, regulating their surface expression in epithelial cells apical

domains. May be involved in the coordination of a diverse range of regulatory

processes for ion transport and second messenger cascades. In complex with

SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion

and modulate the trafficking and the activity of the associated membrane proteins.

May play a role in the cellular mechanisms associated with multidrug resistance

through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR

chloride channel activity. May function to connect SCARB1 with the cellular

machineries for intracellular cholesterol transport and/or metabolism. May be

involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate

cotransport therefore playing an important role in tubule function (By similarity).
PDZK1 Sequence databases
EMBL DDBJ GenBank
PDZK1 3D structure databases
ModBase
PDZK1 Protein-protein interaction databases
STRING
PDZK1 Proteomic databases
PRIDE
PDZK1 Genome annotation databases
Ensembl GeneID KEGG UCSC
PDZK1 Organism-specific databases
CTD MGI
PDZK1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
PDZK1 Gene expression databases
Bgee ArrayExpress Genevestigator
PDZK1 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.