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MOUSE Bbs4 (aa 1-520 )
Bbs4 Swiss-Prot #
Q8C1Z7
Bbs4 Protein names
Bardet-Biedl syndrome 4 protein homolog
Bbs4 Gene names
Bbs4
Organism
Mus musculus (Mouse)
Bbs4 Entry name
BBS4_MOUSE

Bbs4 Codon-optimized cDNA Clone
Bbs4 CDNA Cat#
RPY1268
Tag
cDNA Bbs4 contains A 6x histidine tag
Condon optimized Bbs4 cDNA Formulation
Liquid
Condon optimized Bbs4 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Bbs4 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Bbs4 Protein
Recombinant Bbs4 Protein Cat#
PY1268
Bbs4 Protein Source
Recombinant protein
Recombinant Bbs4 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Bbs4 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Bbs4 Protein Activity
N/A
Tag
Recombinant Bbs4 contains A 6x histidine tag
Recombinant Bbs4 cDNA Formulation
Liquid
Recombinant Bbs4 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Bbs4 Protein or cDNA
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Bbs4 Protein family
BBS4 family
Bbs4 Subcellular locations
Cytoplasm > cytoskeleton > centrosome. Cell projection > cilium membrane. Cytoplasm.
Bbs4 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: May be required for the dynein-mediated transport of pericentriolar

proteins to the centrosome. Required for microtubule anchoring at the centrosome

but not for microtubule nucleation. The BBSome complex is required for

ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic

function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes

to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium

and promotes extension of the ciliary membrane. Firstly the BBSome associates

with the ciliary membrane and binds to Rabin8, the guanosyl exchange factor (GEF)

for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and

fusion of carrier vesicles to the base of the ciliary membrane (By similarity).
Bbs4 Sequence databases
EMBL DDBJ GenBank
Bbs4 3D structure databases
ModBase
Bbs4 Protein-protein interaction databases
STRING
Bbs4 Proteomic databases
PRIDE
Bbs4 Genome annotation databases
Ensembl GeneID KEGG UCSC
Bbs4 Organism-specific databases
CTD MGI
Bbs4 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Bbs4 Gene expression databases
Bgee ArrayExpress Genevestigator
Bbs4 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.