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Mouse Shc1 (aa 1-579 )
Shc1 Swiss - Prot #
P98083
Shc1 Protein names
SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-

containing-transforming protein C1) (SH2 domain protein C1)
Shc1 Gene names
Shc1 Shc ShcA
Organism
Mus musculus (Mouse)
Shc1 Entry name
SHC1_MOUSE

Shc1 Codon-optimized cDNA Clone
Shc1 CDNA Cat#
RPY1412
Tag
cDNA Shc1 contains A 6x histidine tag
Condon optimized Shc1 cDNA Formulation
Liquid
Condon optimized Shc1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Shc1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Shc1 Protein
Recombinant Shc1 Protein Cat#
PY1412
Shc1 Protein Source
Recombinant protein
Recombinant Shc1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Shc1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Shc1 Protein Activity
N/A
Tag
Recombinant Shc1 contains A 6x histidine tag
Recombinant Shc1 protein Formulation
Liquid
Recombinant Shc1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Shc1Protein or cDNA
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Shc1’s Protein family
Shc1’s Subcellular locations
Cytoplasm. Mitochondrion matrix. Mitochondrion.
Shc1’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Signaling adapter that couples activated growth factor receptors to

signaling pathway. Isoform p47Shc and isoform p52Shc, once phosphorylated,

couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS

complex and are implicated in the cytoplasmic propagation of mitogenic signals.

Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling

cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras

activation, but is involved in signal transduction pathways that regulate the cellular

response to oxidative stress and life span. Isoform p66Shc acts as a downstream

target of the tumor suppressor p53 and is indispensable for the ability of stress-

activated p53 to induce elevation of intracellular oxidants, cytochrome c release and

apoptosis. The expression of isoform p66Shc has been correlated with life span.
Shc1 Sequence databases
EMBL DDBJ GenBank
Shc1 3D structure databases
ModBase
Shc1’s Protein-protein interaction databases
STRING
Shc1’s Proteomic databases
PRIDE
Shc1’s Genome annotation databases
Ensembl GeneID KEGG UCSC
Shc1’s Organism-specific databases
CTD MGI
Shc1’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Shc1’s Gene expression databases
Bgee ArrayExpress Genevestigator
Shc1’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.