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Mouse Nf2 (aa 1-596 )
Nf2 Swiss - Prot #
P46662
Nf2 Protein names
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin)
Nf2 Gene names
Nf2 Nf-2
Organism
Mus musculus (Mouse)
Nf2 Entry name
MERL_MOUSE

Nf2 Codon-optimized cDNA Clone
Nf2 CDNA Cat#
RPY1478
Tag
cDNA Nf2 contains A 6x histidine tag
Condon optimized Nf2 cDNA Formulation
Liquid
Condon optimized Nf2 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Nf2 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Nf2 Protein
Recombinant Nf2 Protein Cat#
PY1478
Nf2 Protein Source
Recombinant protein
Recombinant Nf2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Nf2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Nf2 Protein Activity
N/A
Tag
Recombinant Nf2 contains A 6x histidine tag
Recombinant Nf2 protein Formulation
Liquid
Recombinant Nf2 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
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Nf2’s Protein family
Nf2’s Subcellular locations
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cytoplasm >

cytoskeleton. Nucleus.
Nf2’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling

pathway, a signaling pathway that plays a pivotal role in tumor suppression by

restricting proliferation and promoting apoptosis. Along with WWC1 can

synergistically induce the phosphorylation of LATS1 and LATS2 and can probably

function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May

act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2

and impairing its stimulating activity. Suppresses cell proliferation and

tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-

protein ligase complex (By similarity). Plays a role in lens development and is

required for complete fiber cell terminal differentiation, maintenance of cell polarity

and separation of the lens vesicle from the corneal epithelium.
Nf2 Sequence databases
EMBL DDBJ GenBank
Nf2 3D structure databases
ModBase
Nf2’s Protein-protein interaction databases
STRING
Nf2’s Proteomic databases
PRIDE
Nf2’s Genome annotation databases
Ensembl GeneID KEGG UCSC
Nf2’s Organism-specific databases
CTD MGI
Nf2’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Nf2’s Gene expression databases
Bgee ArrayExpress Genevestigator
Nf2’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.