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Human RPA1 (aa 1-616 )
RPA1 Swiss - Prot #
P27694
RPA1 Protein names
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein

1) (RF-A protein 1) (Single-stranded DNA-binding protein)
RPA1 Gene names
RPA1 REPA1 RPA70
Organism
Homo sapiens (Human)
RPA1 Entry name
RFA1_HUMAN

RPA1 Codon-optimized cDNA Clone
RPA1 CDNA Cat#
RPY1525
Tag
cDNA RPA1 contains A 6x histidine tag
Condon optimized RPA1 cDNA Formulation
Liquid
Condon optimized RPA1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized RPA1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant RPA1 Protein
Recombinant RPA1 Protein Cat#
PY1525
RPA1 Protein Source
Recombinant protein
Recombinant RPA1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant RPA1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant RPA1 Protein Activity
N/A
Tag
Recombinant RPA1 contains A 6x histidine tag
Recombinant RPA1 protein Formulation
Liquid
Recombinant RPA1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
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RPA1’s Protein family
Replication factor A protein 1 family
RPA1’s Subcellular locations
Nucleus.
RPA1’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Plays an essential role in several cellular processes in DNA

metabolism including replication, recombination and DNA repair. Binds and

subsequently stabilizes single-stranded DNA intermediates and thus prevents

complementary DNA from reannealing.; FUNCTION: Functions as component of

the alternative replication protein A complex (aRPA). aRPA binds single-stranded

DNA and probably plays a role in DNA repair; it does not support chromosomal

DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot

promote efficient priming by DNA polymerase alpha but supports DNA polymerase

delta synthesis in the presence of PCNA and replication factor C (RFC), the dual

incision/excision reaction of nucleotide excision repair and RAD51-dependent

strand exchange.
RPA1 Sequence databases
EMBL DDBJ GenBank
RPA1 3D structure databases
ModBase
RPA1’s Protein-protein interaction databases
STRING
RPA1’s Proteomic databases
PRIDE
RPA1’s Genome annotation databases
Ensembl GeneID KEGG UCSC
RPA1’s Organism-specific databases
CTD MGI
RPA1’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
RPA1’s Gene expression databases
Bgee ArrayExpress Genevestigator
RPA1’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.