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Human SPAST (aa 1-616 )
SPAST Swiss - Prot #
Q9UBP0
SPAST Protein names
Spastin (EC 3.6.4.3) (Spastic paraplegia 4 protein)
SPAST Gene names
SPAST ADPSP FSP2 KIAA1083 SPG4
Organism
Homo sapiens (Human)
SPAST Entry name
SPAST_HUMAN

SPAST Codon-optimized cDNA Clone
SPAST CDNA Cat#
RPY1526
Tag
cDNA SPAST contains A 6x histidine tag
Condon optimized SPAST cDNA Formulation
Liquid
Condon optimized SPAST cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized SPAST cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant SPAST Protein
Recombinant SPAST Protein Cat#
PY1526
SPAST Protein Source
Recombinant protein
Recombinant SPAST Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant SPAST Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant SPAST Protein Activity
N/A
Tag
Recombinant SPAST contains A 6x histidine tag
Recombinant SPAST protein Formulation
Liquid
Recombinant SPAST protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant SPASTProtein or cDNA
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SPAST’s Protein family
AAA ATPase family, Spastin subfamily
SPAST’s Subcellular locations
Membrane; Single-pass membrane protein. Cytoplasm > cytoskeleton > centrosome. Cytoplasm >

cytoskeleton. Cytoplasm > perinuclear region. Endoplasmic reticulum. Endosome. Nucleus. Cytoplasm

> cytoskeleton > spindle.
SPAST’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: ATP-dependent microtubule severing protein. Microtubule severing

may promote reorganization of cellular microtubule arrays and the release of

microtubules from the centrosome following nucleation. Required for membrane

traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the

abscission stage of cytokinesis. May also play a role in axon growth and the

formation of axonal branches.
SPAST Sequence databases
EMBL DDBJ GenBank
SPAST 3D structure databases
ModBase
SPAST’s Protein-protein interaction databases
STRING
SPAST’s Proteomic databases
PRIDE
SPAST’s Genome annotation databases
Ensembl GeneID KEGG UCSC
SPAST’s Organism-specific databases
CTD MGI
SPAST’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
SPAST’s Gene expression databases
Bgee ArrayExpress Genevestigator
SPAST’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.