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Mouse Sh2b2 (aa 1-621 )
Sh2b2 Swiss - Prot #
Q9JID9
Sh2b2 Protein names
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2

domains) (SH2 and PH domain-containing adapter protein APS)
Sh2b2 Gene names
Sh2b2 Aps
Organism
Mus musculus (Mouse)
Sh2b2 Entry name
SH2B2_MOUSE

Sh2b2 Codon-optimized cDNA Clone
Sh2b2 CDNA Cat#
RPY1544
Tag
cDNA Sh2b2 contains A 6x histidine tag
Condon optimized Sh2b2 cDNA Formulation
Liquid
Condon optimized Sh2b2 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Sh2b2 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Sh2b2 Protein
Recombinant Sh2b2 Protein Cat#
PY1544
Sh2b2 Protein Source
Recombinant protein
Recombinant Sh2b2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Sh2b2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Sh2b2 Protein Activity
N/A
Tag
Recombinant Sh2b2 contains A 6x histidine tag
Recombinant Sh2b2 protein Formulation
Liquid
Recombinant Sh2b2 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Sh2b2Protein or cDNA
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Sh2b2’s Protein family
SH2B adapter family
Sh2b2’s Subcellular locations
Cytoplasm. Cell membrane.
Sh2b2’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Adapter protein for several members of the tyrosine kinase receptor

family. Involved in multiple signaling pathways. May be involved in coupling from

immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine

signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced

STAT5 activation, possibly through a masking effect on STAT5 docking sites in

EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal

reorganization via interaction with VAV3 (By similarity).
Sh2b2 Sequence databases
EMBL DDBJ GenBank
Sh2b2 3D structure databases
ModBase
Sh2b2’s Protein-protein interaction databases
STRING
Sh2b2’s Proteomic databases
PRIDE
Sh2b2’s Genome annotation databases
Ensembl GeneID KEGG UCSC
Sh2b2’s Organism-specific databases
CTD MGI
Sh2b2’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Sh2b2’s Gene expression databases
Bgee ArrayExpress Genevestigator
Sh2b2’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.