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Magnetic Separator
Magnetic Beads and Applications
Affinity Magnetic Beads
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Reversed-Phase  Beads
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Antibody Purification & IP
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Antibody Immobilization
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Recombinant Protein
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Mouse Lmna (aa 1-665 )
Lmna Swiss - Prot #
P48678
Lmna Protein names
Prelamin-A/C [Cleaved into: Lamin-A/C]
Lmna Gene names
Lmna Lmn1
Organism
Mus musculus (Mouse)
Lmna Entry name
LMNA_MOUSE

Lmna Codon-optimized cDNA Clone
Lmna CDNA Cat#
RPY1635
Tag
cDNA Lmna contains A 6x histidine tag
Condon optimized Lmna cDNA Formulation
Liquid
Condon optimized Lmna cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Lmna cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Lmna Protein
Recombinant Lmna Protein Cat#
PY1635
Lmna Protein Source
Recombinant protein
Recombinant Lmna Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Lmna Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Lmna Protein Activity
N/A
Tag
Recombinant Lmna contains A 6x histidine tag
Recombinant Lmna protein Formulation
Liquid
Recombinant Lmna protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant LmnaProtein or cDNA
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Lmna’s Protein family
Intermediate filament family
Lmna’s Subcellular locations
Nucleus. Nucleus envelope.
Lmna’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer on the

nucleoplasmic side of the inner nuclear membrane, which is thought to provide a

framework for the nuclear envelope and may also interact with chromatin. Lamin A

and C are present in equal amounts in the lamina of mammals. Play an important

role in nuclear assembly, chromatin organization, nuclear membrane and telomere

dynamics (By similarity).; FUNCTION: Prelamin-A/C can accelerate smooth

muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in

vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic

instability, and premature senescence (By similarity).
Lmna Sequence databases
EMBL DDBJ GenBank
Lmna 3D structure databases
ModBase
Lmna’s Protein-protein interaction databases
STRING
Lmna’s Proteomic databases
PRIDE
Lmna’s Genome annotation databases
Ensembl GeneID KEGG UCSC
Lmna’s Organism-specific databases
CTD MGI
Lmna’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Lmna’s Gene expression databases
Bgee ArrayExpress Genevestigator
Lmna’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.