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Human THOC5 (aa 1-683 )
THOC5 Swiss - Prot #
Q13769
THOC5 Protein names
THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79)

(NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90)
THOC5 Gene names
THOC5 C22orf19 KIAA0983
Organism
Homo sapiens (Human)
THOC5 Entry name
THOC5_HUMAN

THOC5 Codon-optimized cDNA Clone
THOC5 CDNA Cat#
RPY1680
Tag
cDNA THOC5 contains A 6x histidine tag
Condon optimized THOC5 cDNA Formulation
Liquid
Condon optimized THOC5 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized THOC5 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant THOC5 Protein
Recombinant THOC5 Protein Cat#
PY1680
THOC5 Protein Source
Recombinant protein
Recombinant THOC5 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant THOC5 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant THOC5 Protein Activity
N/A
Tag
Recombinant THOC5 contains A 6x histidine tag
Recombinant THOC5 protein Formulation
Liquid
Recombinant THOC5 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
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THOC5’s Protein family
THOC5 family
THOC5’s Subcellular locations
Nucleus. Cytoplasm.
THOC5’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Component the THO subcomplex of the TREX complex. The TREX

complex specifically associates with spliced mRNA and not with unspliced pre-

mRNA. It is recruited to spliced mRNAs by a transcription-independent

mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is

recruited in a splicing- and cap-dependent manner to a region near the 5' end of the

mRNA where it functions in mRNA export. The recruitment occurs via an

interaction between THOC4 and the cap-binding protein NCBP1. The TREX

complex is essential for the export of Kaposi sarcoma-associated herpesvirus

(KSHV) intronless mRNAs and infectious virus production. The recruitment of the

TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV

ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and

the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1

mediated nuclear export of HSP70 mRNA. Regulates the expression of myeloid

transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of

phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of

granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and

plays an integral role in monocytic development.
THOC5 Sequence databases
EMBL DDBJ GenBank
THOC5 3D structure databases
ModBase
THOC5’s Protein-protein interaction databases
STRING
THOC5’s Proteomic databases
PRIDE
THOC5’s Genome annotation databases
Ensembl GeneID KEGG UCSC
THOC5’s Organism-specific databases
CTD MGI
THOC5’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
THOC5’s Gene expression databases
Bgee ArrayExpress Genevestigator
THOC5’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.