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Human PTPRE (aa 1-700 )
PTPRE Swiss - Prot #
P23469
PTPRE Protein names
Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon)

(R-PTP-epsilon) (EC 3.1.3.48)
PTPRE Gene names
PTPRE
Organism
Homo sapiens (Human)
PTPRE Entry name
PTPRE_HUMAN

PTPRE Codon-optimized cDNA Clone
PTPRE CDNA Cat#
RPY1713
Tag
cDNA PTPRE contains A 6x histidine tag
Condon optimized PTPRE cDNA Formulation
Liquid
Condon optimized PTPRE cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized PTPRE cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant PTPRE Protein
Recombinant PTPRE Protein Cat#
PY1713
PTPRE Protein Source
Recombinant protein
Recombinant PTPRE Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant PTPRE Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant PTPRE Protein Activity
N/A
Tag
Recombinant PTPRE contains A 6x histidine tag
Recombinant PTPRE protein Formulation
Liquid
Recombinant PTPRE protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant PTPREProtein or cDNA
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PTPRE’s Protein family
Protein-tyrosine phosphatase family, Receptor class 4 subfamily
PTPRE’s Subcellular locations
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
PTPRE’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Isoform 1 plays a critical role in signaling transduction pathways and

phosphoprotein network topology in red blood cells. May play a role in osteoclast

formation and function (By similarity).; FUNCTION: Isoform 2 acts as a negative

regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-

induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor

substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase

kinase-3 and insulin induced stimulation of glucose uptake (By similarity).;

FUNCTION: Isoform 1 and isoform 2 act as a negative regulator of FceRI-

mediated signal transduction leading to cytokine production and degranulation,

most likely by acting at the level of SYK to affect downstream events such as

phosphorylation of SLP76 and LAT and mobilization of Ca(2+) (By similarity).
PTPRE Sequence databases
EMBL DDBJ GenBank
PTPRE 3D structure databases
ModBase
PTPRE’s Protein-protein interaction databases
STRING
PTPRE’s Proteomic databases
PRIDE
PTPRE’s Genome annotation databases
Ensembl GeneID KEGG UCSC
PTPRE’s Organism-specific databases
CTD MGI
PTPRE’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
PTPRE’s Gene expression databases
Bgee ArrayExpress Genevestigator
PTPRE’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.