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Human SUN2 (aa 1-717 )
SUN2 Swiss - Prot #
Q9UH99
SUN2 Protein names
SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein)

(Rab5IP) (Sad1/unc-84 protein-like 2)
SUN2 Gene names
SUN2 FRIGG KIAA0668 RAB5IP UNC84B
Organism
Homo sapiens (Human)
SUN2 Entry name
SUN2_HUMAN

SUN2 Codon-optimized cDNA Clone
SUN2 CDNA Cat#
RPY1758
Tag
cDNA SUN2 contains A 6x histidine tag
Condon optimized SUN2 cDNA Formulation
Liquid
Condon optimized SUN2 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized SUN2 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant SUN2 Protein
Recombinant SUN2 Protein Cat#
PY1758
SUN2 Protein Source
Recombinant protein
Recombinant SUN2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant SUN2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant SUN2 Protein Activity
N/A
Tag
Recombinant SUN2 contains A 6x histidine tag
Recombinant SUN2 protein Formulation
Liquid
Recombinant SUN2 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant SUN2Protein or cDNA
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SUN2’s Protein family
SUN2’s Subcellular locations
Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass

type II membrane protein.
SUN2’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Component of SUN-protein-containing multivariate complexes also

called LINC complexes which link the nucleoskeleton and cytoskeleton by providing

versatile outer nuclear membrane attachment sites for cytoskeletal filaments.

Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-

associated nuclear (TAN) lines which are bound to F-actin cables and couple the

nucleus to retrograde actin flow during actin-dependent nuclear movement.

Required for interkinetic nuclear migration (INM) and essential for nucleokinesis

and centrosome-nucleus coupling during radial neuronal migration in the cerebral

cortex and during glial migration. Anchors chromosome movement in the prophase

of meiosis and is involved in selective gene expression of coding and non-coding

RNAs needed for gametogenesis. Required for telomere attachment to nuclear

envelope and gametogenesis. May also function on endocytic vesicles as a receptor

for RAB5-GDP and participate in the activation of RAB5.
SUN2 Sequence databases
EMBL DDBJ GenBank
SUN2 3D structure databases
ModBase
SUN2’s Protein-protein interaction databases
STRING
SUN2’s Proteomic databases
PRIDE
SUN2’s Genome annotation databases
Ensembl GeneID KEGG UCSC
SUN2’s Organism-specific databases
CTD MGI
SUN2’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
SUN2’s Gene expression databases
Bgee ArrayExpress Genevestigator
SUN2’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.