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Human DTL (aa 1-730 )
DTL Swiss - Prot #
Q9NZJ0
DTL Protein names
Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless

protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)
DTL Gene names
DTL CDT2 CDW1 DCAF2 L2DTL RAMP
Organism
Homo sapiens (Human)
DTL Entry name
DTL_HUMAN

DTL Codon-optimized cDNA Clone
DTL CDNA Cat#
RPY1800
Tag
cDNA DTL contains A 6x histidine tag
Condon optimized DTL cDNA Formulation
Liquid
Condon optimized DTL cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized DTL cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant DTL Protein
Recombinant DTL Protein Cat#
PY1800
DTL Protein Source
Recombinant protein
Recombinant DTL Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant DTL Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant DTL Protein Activity
N/A
Tag
Recombinant DTL contains A 6x histidine tag
Recombinant DTL protein Formulation
Liquid
Recombinant DTL protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
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DTL’s Protein family
WD repeat cdt2 family
DTL’s Subcellular locations
Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm >

cytoskeleton > centrosome.
DTL’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3

ubiquitin-protein ligase complex required for cell cycle control, DNA damage

response and translesion DNA synthesis. The DCX(DTL) complex, also named

CRL4(CDT2) complex, mediates the polyubiquitination and subsequent

degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to

DNA damage is necessary to ensure proper cell cycle regulation of DNA

replication. CDKN1A/p21(CIP1) degradation during S phase or following UV

irradiation is essential to control replication licensing. Most substrates require

their interaction with PCNA for their polyubiquitination: substrates interact with

PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit

the DCX(DTL) complex, leading to their degradation. In undamaged proliferating

cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of

PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
DTL Sequence databases
EMBL DDBJ GenBank
DTL 3D structure databases
ModBase
DTL’s Protein-protein interaction databases
STRING
DTL’s Proteomic databases
PRIDE
DTL’s Genome annotation databases
Ensembl GeneID KEGG UCSC
DTL’s Organism-specific databases
CTD MGI
DTL’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
DTL’s Gene expression databases
Bgee ArrayExpress Genevestigator
DTL’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.