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Rat Jup (aa 1-745 )
Jup Swiss - Prot #
Q6P0K8
Jup Protein names
Junction plakoglobin
Jup Gene names
Jup
Organism
Rattus norvegicus (Rat)
Jup Entry name
PLAK_RAT

Jup Codon-optimized cDNA Clone
Jup CDNA Cat#
RPY1841
Tag
cDNA Jup contains A 6x histidine tag
Condon optimized Jup cDNA Formulation
Liquid
Condon optimized Jup cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Jup cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Jup Protein
Recombinant Jup Protein Cat#
PY1841
Jup Protein Source
Recombinant protein
Recombinant Jup Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Jup Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Jup Protein Activity
N/A
Tag
Recombinant Jup contains A 6x histidine tag
Recombinant Jup protein Formulation
Liquid
Recombinant Jup protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant JupProtein or cDNA
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Jup’s Protein family
Beta-catenin family
Jup’s Subcellular locations
Cell junction > adherens junction. Cell junction > desmosome. Cytoplasm > cytoskeleton. Membrane;

Peripheral membrane protein.
Jup’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Common junctional plaque protein. The membrane-associated

plaques are architectural elements in an important strategic position to influence

the arrangement and function of both the cytoskeleton and the cells within the tissue.

The presence of plakoglobin in both the desmosomes and in the intermediate

junctions suggests that it plays a central role in the structure and function of

submembranous plaques. Acts as a substrate for VE-PTP and is required by it to

stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-

cadherin/catenin adhesion complexes which are proposed to couple cadherins to

the actin cytoskeleton (By similarity).
Jup Sequence databases
EMBL DDBJ GenBank
Jup 3D structure databases
ModBase
Jup’s Protein-protein interaction databases
STRING
Jup’s Proteomic databases
PRIDE
Jup’s Genome annotation databases
Ensembl GeneID KEGG UCSC
Jup’s Organism-specific databases
CTD MGI
Jup’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Jup’s Gene expression databases
Bgee ArrayExpress Genevestigator
Jup’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.