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Human ARHGAP24 (aa 1-748 )
ARHGAP24 Swiss - Prot #
Q8N264
ARHGAP24 Protein names
Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and

CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-

activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP)
ARHGAP24 Gene names
ARHGAP24 FILGAP
Organism
Homo sapiens (Human)
ARHGAP24 Entry name
RHG24_HUMAN

ARHGAP24 Codon-optimized cDNA Clone
ARHGAP24 CDNA Cat#
RPY1850
Tag
cDNA ARHGAP24 contains A 6x histidine tag
Condon optimized ARHGAP24 cDNA Formulation
Liquid
Condon optimized ARHGAP24 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized ARHGAP24 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant ARHGAP24 Protein
Recombinant ARHGAP24 Protein Cat#
PY1850
ARHGAP24 Protein Source
Recombinant protein
Recombinant ARHGAP24 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant ARHGAP24 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant ARHGAP24 Protein Activity
N/A
Tag
Recombinant ARHGAP24 contains A 6x histidine tag
Recombinant ARHGAP24 protein Formulation
Liquid
Recombinant ARHGAP24 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant ARHGAP24Protein or cDNA
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ARHGAP24’s Protein family
ARHGAP24’s Subcellular locations
Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell junction > focal adhesion. Cell

projection.
ARHGAP24’s FUNCTION (According to UniProtKB/Swiss-
FUNCTION: Rho GTPase-activating protein involved in cell polarity, cell
Prot)
morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-

type GTPase by converting it to an inactive GDP-bound state. Controls actin

remodeling by inactivating Rac downstream of Rho leading to suppress leading

edge protrusion and promotes cell retraction to achieve cellular polarity. Able to

suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding

with partial or complete disruption of actin stress fibers and formation of membrane

ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP

involved in modulation of angiogenesis.
ARHGAP24 Sequence databases
EMBL DDBJ GenBank
ARHGAP24 3D structure databases
ModBase
ARHGAP24’s Protein-protein interaction databases
STRING
ARHGAP24’s Proteomic databases
PRIDE
ARHGAP24’s Genome annotation databases
Ensembl GeneID KEGG UCSC
ARHGAP24’s Organism-specific databases
CTD MGI
ARHGAP24’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
ARHGAP24’s Gene expression databases
Bgee ArrayExpress Genevestigator
ARHGAP24’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.