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Human ERCC2 (aa 1-760 )
ERCC2 Swiss - Prot #
P18074
ERCC2 Protein names
TFIIH basal transcription factor complex helicase XPD subunit (EC 3.6.4.12) (Basic

transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA excision repair protein

ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor

complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum

group D-complementing protein)
ERCC2 Gene names
ERCC2 XPD XPDC
Organism
Homo sapiens (Human)
ERCC2 Entry name
ERCC2_HUMAN

ERCC2 Codon-optimized cDNA Clone
ERCC2 CDNA Cat#
RPY1871
Tag
cDNA ERCC2 contains A 6x histidine tag
Condon optimized ERCC2 cDNA Formulation
Liquid
Condon optimized ERCC2 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized ERCC2 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant ERCC2 Protein
Recombinant ERCC2 Protein Cat#
PY1871
ERCC2 Protein Source
Recombinant protein
Recombinant ERCC2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant ERCC2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant ERCC2 Protein Activity
N/A
Tag
Recombinant ERCC2 contains A 6x histidine tag
Recombinant ERCC2 protein Formulation
Liquid
Recombinant ERCC2 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
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ERCC2’s Protein family
Helicase family, RAD3/XPD subfamily
ERCC2’s Subcellular locations
Nucleus. Cytoplasm > cytoskeleton > spindle.
ERCC2’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH

basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by

opening DNA around the damage, and in RNA transcription by RNA polymerase II

by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin

H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D

receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a

role in chromosome segregation. Might have a role in aging process and could

play a causative role in the generation of skin cancers.
ERCC2 Sequence databases
EMBL DDBJ GenBank
ERCC2 3D structure databases
ModBase
ERCC2’s Protein-protein interaction databases
STRING
ERCC2’s Proteomic databases
PRIDE
ERCC2’s Genome annotation databases
Ensembl GeneID KEGG UCSC
ERCC2’s Organism-specific databases
CTD MGI
ERCC2’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
ERCC2’s Gene expression databases
Bgee ArrayExpress Genevestigator
ERCC2’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.