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Human DGCR8 (aa 1-773 )
DGCR8 Swiss - Prot #
Q8WYQ5
DGCR8 Protein names
Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)
DGCR8 Gene names
DGCR8 C22orf12 DGCRK6 LP4941
Organism
Homo sapiens (Human)
DGCR8 Entry name
DGCR8_HUMAN

DGCR8 Codon-optimized cDNA Clone
DGCR8 CDNA Cat#
RPY1883
Tag
cDNA DGCR8 contains A 6x histidine tag
Condon optimized DGCR8 cDNA Formulation
Liquid
Condon optimized DGCR8 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized DGCR8 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant DGCR8 Protein
Recombinant DGCR8 Protein Cat#
PY1883
DGCR8 Protein Source
Recombinant protein
Recombinant DGCR8 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant DGCR8 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant DGCR8 Protein Activity
N/A
Tag
Recombinant DGCR8 contains A 6x histidine tag
Recombinant DGCR8 protein Formulation
Liquid
Recombinant DGCR8 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant DGCR8Protein or cDNA
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DGCR8’s Protein family
DGCR8’s Subcellular locations
Nucleus. Nucleus > nucleolus.
DGCR8’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Component of the microprocessor complex that acts as a RNA- and

heme-binding protein that is involved in the initial step of microRNA (miRNA)

biogenesis. Component of the microprocessor complex that is required to process

primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-

miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a

molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA

junction and directs DROSHA to cleave 11 bp away form the junction to release

hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to

generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as

a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage,

whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is

much less active. Both double-stranded and single-stranded regions of a pri-

miRNA are required for its binding. Involved in the silencing of embryonic stem

cells self-renewal.
DGCR8 Sequence databases
EMBL DDBJ GenBank
DGCR8 3D structure databases
ModBase
DGCR8’s Protein-protein interaction databases
STRING
DGCR8’s Proteomic databases
PRIDE
DGCR8’s Genome annotation databases
Ensembl GeneID KEGG UCSC
DGCR8’s Organism-specific databases
CTD MGI
DGCR8’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
DGCR8’s Gene expression databases
Bgee ArrayExpress Genevestigator
DGCR8’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.