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Human DISC1 (aa 1-854 )
DISC1 Swiss - Prot #
Q9NRI5
DISC1 Protein names
Disrupted in schizophrenia 1 protein
DISC1 Gene names
DISC1 KIAA0457
Organism
Homo sapiens (Human)
DISC1 Entry name
DISC1_HUMAN

DISC1 Codon-optimized cDNA Clone
DISC1 CDNA Cat#
RPY2016
Tag
cDNA DISC1 contains A 6x histidine tag
Condon optimized DISC1 cDNA Formulation
Liquid
Condon optimized DISC1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized DISC1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant DISC1 Protein
Recombinant DISC1 Protein Cat#
PY2016
DISC1 Protein Source
Recombinant protein
Recombinant DISC1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant DISC1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant DISC1 Protein Activity
N/A
Tag
Recombinant DISC1 contains A 6x histidine tag
Recombinant DISC1 protein Formulation
Liquid
Recombinant DISC1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant DISC1Protein or cDNA
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DISC1’s Protein family
DISC1’s Subcellular locations
Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton.
DISC1’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Involved in the regulation of multiple aspects of embryonic and adult

neurogenesis. Required for neural progenitor proliferation in the

ventrical/subventrical zone during embryonic brain development and in the adult

dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural

progenitor proliferation as a positive regulator by modulating GSK3B activity and

CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling

pathway controlling the tempo of the process of newborn neurons integration during

adult neurogenesis, including neuron positioning, dendritic development and

synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction

with CCDC88A. Regulates the migration of early-born granule cell precursors

toward the dentate gyrus during the hippocampal development. Plays a role,

together with PCNT, in the microtubule network formation.
DISC1 Sequence databases
EMBL DDBJ GenBank
DISC1 3D structure databases
ModBase
DISC1’s Protein-protein interaction databases
STRING
DISC1’s Proteomic databases
PRIDE
DISC1’s Genome annotation databases
Ensembl GeneID KEGG UCSC
DISC1’s Organism-specific databases
CTD MGI
DISC1’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
DISC1’s Gene expression databases
Bgee ArrayExpress Genevestigator
DISC1’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.