| DAG1 Swiss - Prot # |
| Q14118 |
| DAG1 Protein names |
| Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan |
| (Alpha-DG); Beta-dystroglycan (Beta-DG)] |
| Organism |
| Homo sapiens (Human) |
| DAG1 Entry name |
| DAG1_HUMAN |
| DAG1 Codon-optimized cDNA Clone |
| Tag |
| cDNA DAG1 contains A 6x histidine tag |
| Condon optimized DAG1 cDNA Formulation |
| Liquid |
| Condon optimized DAG1 cDNA Storage |
| −20℃ to −70℃. Avoid repeated freeze-thaw cycles. |
| Condon optimized DAG1 cDNA Application (s) |
| Applications: 1. Codon-optimized cDNA sequence designed for |
| recombinant protein production in both E.coli and Mammalian cell. The |
| cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2. |
| May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant DAG1 Protein Cat# |
| PY2085 |
| DAG1 Protein Source |
| Recombinant protein |
| Recombinant DAG1 Protein Applications |
| Western Blot, may be used for other applications determined by user |
| Recombinant DAG1 Protein Purity |
| >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant DAG1 Protein Activity |
| N/A |
| Tag |
| Recombinant DAG1 contains A 6x histidine tag |
| Recombinant DAG1 protein Formulation |
| Liquid |
| Recombinant DAG1 protein Storage |
| −20℃ to −70℃. Avoid repeated freeze-thaw cycles. |
| DAG1’s Subcellular locations |
| Secreted > extracellular space. Cell membrane; Single-pass type I membrane protein. Cytoplasm > |
| cytoskeleton. Nucleus > nucleoplasm. |
| DAG1’s FUNCTION (According to UniProtKB/Swiss-Prot) |
| FUNCTION: The dystroglycan complex is involved in a number of processes |
| including laminin and basement membrane assembly, sacrolemmal stability, cell |
| survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial |
| polarization.; FUNCTION: Alpha-dystroglycan is an extracellular peripheral |
| glycoprotein that acts as a receptor for both extracellular matrix proteins containing |
| laminin-G domains, and for certain adenoviruses. Receptor for laminin-2 (LAMA2) |
| and agrin in peripheral nerve Schwann cells. Also acts as a receptor for M.leprae |
| in peripheral nerve Schwann cells but only in the presence of the G-domain of |
| LAMA2, and for lymphocytic choriomeningitis virus, Old World Lassa fever virus, |
| and clade C New World arenaviruses.; FUNCTION: Beta-dystroglycan is a |
| transmembrane protein that plays important roles in connecting the extracellular |
| matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- |
| muscle tissues. Receptor for both DMD and UTRN and, through these |
| interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion- |
| mediated signaling and implicated in cell polarity. |
| DAG1 3D structure databases |
| ModBase |
| DAG1’s Protein-protein interaction databases |
| STRING |
| DAG1’s Proteomic databases |
| PRIDE |
| DAG1’s Organism-specific databases |
| CTD |
MGI |
| FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS. |
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