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Rat Cyld (aa 1-953 )
Cyld Swiss - Prot #
Q66H62
Cyld Protein names
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD)

(Ubiquitin thiolesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
Cyld Gene names
Cyld Cyld1
Organism
Rattus norvegicus (Rat)
Cyld Entry name
CYLD_RAT

Cyld Codon-optimized cDNA Clone
Cyld CDNA Cat#
RPY2155
Tag
cDNA Cyld contains A 6x histidine tag
Condon optimized Cyld cDNA Formulation
Liquid
Condon optimized Cyld cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Cyld cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cyld Protein
Recombinant Cyld Protein Cat#
PY2155
Cyld Protein Source
Recombinant protein
Recombinant Cyld Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Cyld Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Cyld Protein Activity
N/A
Tag
Recombinant Cyld contains A 6x histidine tag
Recombinant Cyld protein Formulation
Liquid
Recombinant Cyld protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant CyldProtein or cDNA
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Cyld’s Protein family
Peptidase C67 family
Cyld’s Subcellular locations
Cytoplasm. Cytoplasm > perinuclear region. Cytoplasm > cytoskeleton. Cell membrane; Peripheral

membrane protein; Cytoplasmic side.
Cyld’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains.

Has endodeubiquitinase activity. Plays an important role in the regulation of

pathways leading to NF-kappa-B activation. Contributes to the regulation of cell

survival, proliferation and differentiation via its effects on NF-kappa-B activation.

Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes

acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the

regulation of microtubule dynamics, and thereby contributes to the regulation of cell

proliferation, cell polarization, cell migration, and angiogenesis. Required for

normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of

NF-kappa-B (By similarity). Plays a role in the regulation of inflammation and the

innate immune response, via its effects on NF-kappa-B activation. Dispensable for

the maturation of intrathymic natural killer cells, but required for the continued

survival of immature natural killer cells. Negatively regulates TNFRSF11A

signaling and osteoclastogenesis (By similarity).
Cyld Sequence databases
EMBL DDBJ GenBank
Cyld 3D structure databases
ModBase
Cyld’s Protein-protein interaction databases
STRING
Cyld’s Proteomic databases
PRIDE
Cyld’s Genome annotation databases
Ensembl GeneID KEGG UCSC
Cyld’s Organism-specific databases
CTD MGI
Cyld’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Cyld’s Gene expression databases
Bgee ArrayExpress Genevestigator
Cyld’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.