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Human PELP1 (aa 1-1130 )
PELP1 Swiss - Prot #
Q8IZL8
PELP1 Protein names
Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of

estrogen receptor) (Transcription factor HMX3)
PELP1 Gene names
PELP1 HMX3 MNAR
Organism
Homo sapiens (Human)
PELP1 Entry name
PELP1_HUMAN

PELP1 Codon-optimized cDNA Clone
PELP1 CDNA Cat#
RPY2345
Tag
cDNA PELP1 contains A 6x histidine tag
Condon optimized PELP1 cDNA Formulation
Liquid
Condon optimized PELP1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized PELP1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant PELP1 Protein
Recombinant PELP1 Protein Cat#
PY2345
PELP1 Protein Source
Recombinant protein
Recombinant PELP1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant PELP1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant PELP1 Protein Activity
N/A
Tag
Recombinant PELP1 contains A 6x histidine tag
Recombinant PELP1 protein Formulation
Liquid
Recombinant PELP1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant PELP1Protein or cDNA
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PELP1’s Protein family
PELP1’s Subcellular locations
Nucleus. Cytoplasm.
PELP1’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Coactivator of estrogen receptor-mediated transcription and a

corepressor of other nuclear hormone receptors and sequence-specific

transcription factors. Plays a role in estrogen receptor (ER) genomic activity when

present in the nuclear compartment by activating the ER target genes in a hormonal

stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC

and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle

progression by interacting with RB1. May have important functional implications in

ER/growth factor cross-talk. Interacts with several growth factor signaling

components including EGFR and HRS. Involved in nuclear receptor signaling via

its interaction with AR and NR3C1. May promote tumorigenesis via its interaction

with and modulation of several oncogenes including SRC, PI3K, STAT3 and

EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated

cytoskeleton changes and cell migration via its interaction with SRC and PI3K.
PELP1 Sequence databases
EMBL DDBJ GenBank
PELP1 3D structure databases
ModBase
PELP1’s Protein-protein interaction databases
STRING
PELP1’s Proteomic databases
PRIDE
PELP1’s Genome annotation databases
Ensembl GeneID KEGG UCSC
PELP1’s Organism-specific databases
CTD MGI
PELP1’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
PELP1’s Gene expression databases
Bgee ArrayExpress Genevestigator
PELP1’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.