| Inpp5d Swiss - Prot # |
| P97573 |
| Inpp5d Protein names |
| Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.n1) (SH2 domain- |
| containing inositol-5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) |
| Inpp5d Gene names |
| Inpp5d Ship Ship1 |
| Organism |
| Rattus norvegicus (Rat) |
| Inpp5d Entry name |
| SHIP1_RAT |
| Inpp5d Codon-optimized cDNA Clone |
| Tag |
| cDNA Inpp5d contains A 6x histidine tag |
| Condon optimized Inpp5d cDNA Formulation |
| Liquid |
| Condon optimized Inpp5d cDNA Storage |
| −20℃ to −70℃. Avoid repeated freeze-thaw cycles. |
| Condon optimized Inpp5d cDNA Application (s) |
| Applications: 1. Codon-optimized cDNA sequence designed for |
| recombinant protein production in both E.coli and Mammalian cell. The |
| cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2. |
| May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Inpp5d Protein |
| Recombinant Inpp5d Protein Cat# |
| PY2378 |
| Inpp5d Protein Source |
| Recombinant protein |
| Recombinant Inpp5d Protein Applications |
| Western Blot, may be used for other applications determined by user |
| Recombinant Inpp5d Protein Purity |
| >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant Inpp5d Protein Activity |
| N/A |
| Tag |
| Recombinant Inpp5d contains A 6x histidine tag |
| Recombinant Inpp5d protein Formulation |
| Liquid |
| Recombinant Inpp5d protein Storage |
| −20℃ to −70℃. Avoid repeated freeze-thaw cycles. |
| Inpp5d’s Protein family |
| Inositol-1,4,5-trisphosphate 5-phosphatase family |
| Inpp5d’s Subcellular locations |
| Cytoplasm. Membrane; Peripheral membrane protein. |
| Inpp5d’s FUNCTION (According to UniProtKB/Swiss-Prot) |
| FUNCTION: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes |
| the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to |
| produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3- |
| kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. |
| Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a |
| central role in terminating signal transduction from activating |
| immune/hematopoietic cell receptor systems. Acts as a negative regulator of |
| myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune |
| cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK |
| signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage |
| programming, phagocytosis and activation and is required for endotoxin tolerance. |
| Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and |
| modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil |
| migration, by governing the formation of the leading edge and polarization required |
| for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. |
| Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent |
| expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of |
| the higher inositol polyphosphates like InsP6 (By similarity). |
| Inpp5d 3D structure databases |
| ModBase |
| Inpp5d’s Protein-protein interaction databases |
| STRING |
| Inpp5d’s Proteomic databases |
| PRIDE |
| Inpp5d’s Organism-specific databases |
| CTD |
MGI |
| FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS. |
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