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Human TBCD (aa 1-1192 )
TBCD Swiss - Prot #
Q9BTW9
TBCD Protein names
Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding

cofactor D)
TBCD Gene names
TBCD KIAA0988 SSD1 TFCD PP1096
Organism
Homo sapiens (Human)
TBCD Entry name
TBCD_HUMAN

TBCD Codon-optimized cDNA Clone
TBCD CDNA Cat#
RPY2380
Tag
cDNA TBCD contains A 6x histidine tag
Condon optimized TBCD cDNA Formulation
Liquid
Condon optimized TBCD cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized TBCD cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant TBCD Protein
Recombinant TBCD Protein Cat#
PY2380
TBCD Protein Source
Recombinant protein
Recombinant TBCD Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant TBCD Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant TBCD Protein Activity
N/A
Tag
Recombinant TBCD contains A 6x histidine tag
Recombinant TBCD protein Formulation
Liquid
Recombinant TBCD protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant TBCDProtein or cDNA
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TBCD’s Protein family
TBCD family
TBCD’s Subcellular locations
Cell junction > tight junction. Lateral cell membrane. Cytoplasm. Cell junction > adherens junction.
TBCD’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Tubulin-folding protein; involved in the first step of the tubulin folding

pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin

(TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact

with beta tubulin is regulated via its interaction with ARL2. Induces microtubule

disruption in absence of ARL2. Increases degradation of beta tubulin, when

overexpressed in polarized cells. Promotes epithelial cell detachment, a process

antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the

lateral cell membrane.
TBCD Sequence databases
EMBL DDBJ GenBank
TBCD 3D structure databases
ModBase
TBCD’s Protein-protein interaction databases
STRING
TBCD’s Proteomic databases
PRIDE
TBCD’s Genome annotation databases
Ensembl GeneID KEGG UCSC
TBCD’s Organism-specific databases
CTD MGI
TBCD’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
TBCD’s Gene expression databases
Bgee ArrayExpress Genevestigator
TBCD’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.