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Mouse Diaph1 (aa 1-1255 )
Diaph1 Swiss - Prot #
O08808
Diaph1 Protein names
Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (p140mDIA) (mDIA1)
Diaph1 Gene names
Diaph1 Diap1
Organism
Mus musculus (Mouse)
Diaph1 Entry name
DIAP1_MOUSE

Diaph1 Codon-optimized cDNA Clone
Diaph1 CDNA Cat#
RPY2416
Tag
cDNA Diaph1 contains A 6x histidine tag
Condon optimized Diaph1 cDNA Formulation
Liquid
Condon optimized Diaph1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Diaph1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Diaph1 Protein
Recombinant Diaph1 Protein Cat#
PY2416
Diaph1 Protein Source
Recombinant protein
Recombinant Diaph1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Diaph1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Diaph1 Protein Activity
N/A
Tag
Recombinant Diaph1 contains A 6x histidine tag
Recombinant Diaph1 protein Formulation
Liquid
Recombinant Diaph1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
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Diaph1’s Protein family
Formin homology family, Diaphanous subfamily
Diaph1’s Subcellular locations
Cell membrane. Cell projection > ruffle membrane. Cytoplasm > cytoskeleton.
Diaph1’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Acts in a Rho-dependent manner to recruit PFY1 to the membrane.

Required for the assembly of F-actin structures, such as actin cables and stress

fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and

slows down actin polymerization and depolymerization. Required for cytokinesis,

and transcriptional activation of the serum response factor. DFR proteins couple

Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics.

Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and

promote cell migration. Has neurite outgrowth promoting activity.
Diaph1 Sequence databases
EMBL DDBJ GenBank
Diaph1 3D structure databases
ModBase
Diaph1’s Protein-protein interaction databases
STRING
Diaph1’s Proteomic databases
PRIDE
Diaph1’s Genome annotation databases
Ensembl GeneID KEGG UCSC
Diaph1’s Organism-specific databases
CTD MGI
Diaph1’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Diaph1’s Gene expression databases
Bgee ArrayExpress Genevestigator
Diaph1’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.