| Inppl1 Swiss - Prot # |
| Q9WVR3 |
| Inppl1 Protein names |
| Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.n1) (Inositol |
| polyphosphate phosphatase-like protein 1) (INPPL-1) (SH2 domain-containing inositol-5'- |
| phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) |
| Inppl1 Gene names |
| Inppl1 Ship2 |
| Organism |
| Rattus norvegicus (Rat) |
| Inppl1 Entry name |
| SHIP2_RAT |
| Inppl1 Codon-optimized cDNA Clone |
| Tag |
| cDNA Inppl1 contains A 6x histidine tag |
| Condon optimized Inppl1 cDNA Formulation |
| Liquid |
| Condon optimized Inppl1 cDNA Storage |
| −20℃ to −70℃. Avoid repeated freeze-thaw cycles. |
| Condon optimized Inppl1 cDNA Application (s) |
| Applications: 1. Codon-optimized cDNA sequence designed for |
| recombinant protein production in both E.coli and Mammalian cell. The |
| cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2. |
| May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Inppl1 Protein |
| Recombinant Inppl1 Protein Cat# |
| PY2420 |
| Inppl1 Protein Source |
| Recombinant protein |
| Recombinant Inppl1 Protein Applications |
| Western Blot, may be used for other applications determined by user |
| Recombinant Inppl1 Protein Purity |
| >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant Inppl1 Protein Activity |
| N/A |
| Tag |
| Recombinant Inppl1 contains A 6x histidine tag |
| Recombinant Inppl1 protein Formulation |
| Liquid |
| Recombinant Inppl1 protein Storage |
| −20℃ to −70℃. Avoid repeated freeze-thaw cycles. |
| Inppl1’s Protein family |
| Inositol-1,4,5-trisphosphate 5-phosphatase family |
| Inppl1’s Subcellular locations |
| Cytoplasm > cytosol. Cytoplasm > cytoskeleton > actin patch. Membrane; Peripheral membrane |
| Inppl1’s FUNCTION (According to UniProtKB/Swiss-Prot) |
| FUNCTION: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes |
| the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to |
| produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3- |
| kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin |
| signaling, although the precise molecular mechanisms and signaling pathways |
| remain unclear. While overexpression reduces both insulin-stimulated MAP kinase |
| and Akt activation, its absence does not affect insulin signaling or GLUT4 |
| trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but |
| not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway |
| that regulates actin cytoskeleton remodeling. Required for the maintenance and |
| dynamic remodeling of actin structures as well as in endocytosis, having a major |
| impact on ligand-induced EGFR internalization and degradation. Participates in |
| regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 |
| thereby regulating membrane ruffling. Regulates cell adhesion and cell spreading. |
| Required for HGF-mediated lamellipodium formation, cell scattering and |
| spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by |
| inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of |
| neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial |
| protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative |
| regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from |
| the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating |
| signal transduction from activating immune/hematopoietic cell receptor systems. |
| Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by |
| EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating |
| the PI3K-PKB pathway, possibly by inhibiting PKB activity. Down-regulates Fc- |
| gamma-R-mediated phagocytosis in macrophages independently of |
| INPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent gene |
| transcription by regulating macrophage colony-stimulating factor (M-CSF)- |
| induced signaling. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the |
| levels of the higher inositol polyphosphates like InsP6. |
| Inppl1 3D structure databases |
| ModBase |
| Inppl1’s Protein-protein interaction databases |
| STRING |
| Inppl1’s Proteomic databases |
| PRIDE |
| Inppl1’s Organism-specific databases |
| CTD |
MGI |
| FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS. |
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