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Human SMARCA2 (aa 1-1590 )
SMARCA2 Swiss - Prot #
P51531
SMARCA2 Protein names
Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase

SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM)

(SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin

subfamily A member 2)
SMARCA2 Gene names
SMARCA2 BAF190B BRM SNF2A SNF2L2
Organism
Homo sapiens (Human)
SMARCA2 Entry name
SMCA2_HUMAN

SMARCA2 Codon-optimized cDNA Clone
SMARCA2 CDNA Cat#
RPY2565
Tag
cDNA SMARCA2 contains A 6x histidine tag
Condon optimized SMARCA2 cDNA Formulation
Liquid
Condon optimized SMARCA2 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized SMARCA2 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant SMARCA2 Protein
Recombinant SMARCA2 Protein Cat#
PY2565
SMARCA2 Protein Source
Recombinant protein
Recombinant SMARCA2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant SMARCA2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant SMARCA2 Protein Activity
N/A
Tag
Recombinant SMARCA2 contains A 6x histidine tag
Recombinant SMARCA2 protein Formulation
Liquid
Recombinant SMARCA2 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant SMARCA2Protein or cDNA
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SMARCA2’s Protein family
SNF2/RAD54 helicase family
SMARCA2’s Subcellular locations
Nucleus.
SMARCA2’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Transcriptional coactivator cooperating with nuclear hormone

receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled

transcription regulation via its association with the WINAC complex, a chromatin-

remodeling complex recruited by vitamin D receptor (VDR), which is required for

the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to

the neural progenitors-specific chromatin remodeling complex (npBAF complex)

and the neuron-specific chromatin remodeling complex (nBAF complex). During

neural development a switch from a stem/progenitor to a post-mitotic chromatin

remodeling mechanism occurs as neurons exit the cell cycle and become

committed to their adult state. The transition from proliferating neural

stem/progenitor cells to post-mitotic neurons requires a switch in subunit

composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis

and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A

and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B

and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes

(nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity

of the multipotent neural stem cells. The nBAF complex along with CREST plays a

role regulating the activity of genes essential for dendrite growth (By similarity).
SMARCA2 Sequence databases
EMBL DDBJ GenBank
SMARCA2 3D structure databases
ModBase
SMARCA2’s Protein-protein interaction databases
STRING
SMARCA2’s Proteomic databases
PRIDE
SMARCA2’s Genome annotation databases
Ensembl GeneID KEGG UCSC
SMARCA2’s Organism-specific databases
CTD MGI
SMARCA2’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
SMARCA2’s Gene expression databases
Bgee ArrayExpress Genevestigator
SMARCA2’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.