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Mouse Nisch (aa 1-1593 )
Nisch Swiss - Prot #
Q80TM9
Nisch Protein names
Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor I-1-like protein)

(Imidazoline-1 receptor) (I1R)
Nisch Gene names
Nisch Kiaa0975
Organism
Mus musculus (Mouse)
Nisch Entry name
NISCH_MOUSE

Nisch Codon-optimized cDNA Clone
Nisch CDNA Cat#
RPY2568
Tag
cDNA Nisch contains A 6x histidine tag
Condon optimized Nisch cDNA Formulation
Liquid
Condon optimized Nisch cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Nisch cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Nisch Protein
Recombinant Nisch Protein Cat#
PY2568
Nisch Protein Source
Recombinant protein
Recombinant Nisch Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Nisch Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Nisch Protein Activity
N/A
Tag
Recombinant Nisch contains A 6x histidine tag
Recombinant Nisch protein Formulation
Liquid
Recombinant Nisch protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
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Nisch’s Protein family
Nisch’s Subcellular locations
Cell membrane. Cytoplasm. Early endosome. Recycling endosome.
Nisch’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Acts either as the functional imidazoline-1 receptor (I1R) candidate

or as a membrane-associated mediator of the I1R signaling. Binds numerous

imidazoline ligands that induces initiation of cell-signaling cascades triggering to

cell survival, growth and migration. Its activation by the agonist rilmenidine induces

an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and

MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-

evoked hypotension (By similarity). Blocking its activation with efaroxan abolished

rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM

neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction

pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and

inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by

interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and

cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing

LIMK1 'Tyr-508' phosphorylation. Inhibits Rac-induced cell migration and invasion

in breast and colon epithelial cells. Inhibits lamellipodia formation, when

overexpressed. Plays a role in protection against apoptosis (By similarity). Involved

in association with IRS4 in the enhancement of insulin activation of MAPK1 and

MAPK3 (By similarity). When overexpressed, induces a redistribution of cell

surface ITGA5 integrin to intracellular endosomal structures (By similarity).
Nisch Sequence databases
EMBL DDBJ GenBank
Nisch 3D structure databases
ModBase
Nisch’s Protein-protein interaction databases
STRING
Nisch’s Proteomic databases
PRIDE
Nisch’s Genome annotation databases
Ensembl GeneID KEGG UCSC
Nisch’s Organism-specific databases
CTD MGI
Nisch’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Nisch’s Gene expression databases
Bgee ArrayExpress Genevestigator
Nisch’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.