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Human XRN1 (aa 1-1706 )
XRN1 Swiss - Prot #
Q8IZH2
XRN1 Protein names
5'-3' exoribonuclease 1 (EC 3.1.11.-) (Strand-exchange protein 1 homolog)
XRN1 Gene names
XRN1 SEP1
Organism
Homo sapiens (Human)
XRN1 Entry name
XRN1_HUMAN

XRN1 Codon-optimized cDNA Clone
XRN1 CDNA Cat#
RPY2597
Tag
cDNA XRN1 contains A 6x histidine tag
Condon optimized XRN1 cDNA Formulation
Liquid
Condon optimized XRN1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized XRN1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant XRN1 Protein
Recombinant XRN1 Protein Cat#
PY2597
XRN1 Protein Source
Recombinant protein
Recombinant XRN1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant XRN1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant XRN1 Protein Activity
N/A
Tag
Recombinant XRN1 contains A 6x histidine tag
Recombinant XRN1 protein Formulation
Liquid
Recombinant XRN1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant XRN1Protein or cDNA
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XRN1’s Protein family
5'-3' exonuclease family
XRN1’s Subcellular locations
Cytoplasm.
XRN1’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Major 5'-3' exoribonuclease involved in mRNA decay. Required for

the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The

kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and

monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in

replication-dependent histone mRNA degradation. May act as a tumor suppressor

protein in osteogenic sarcoma (OGS).
XRN1 Sequence databases
EMBL DDBJ GenBank
XRN1 3D structure databases
ModBase
XRN1’s Protein-protein interaction databases
STRING
XRN1’s Proteomic databases
PRIDE
XRN1’s Genome annotation databases
Ensembl GeneID KEGG UCSC
XRN1’s Organism-specific databases
CTD MGI
XRN1’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
XRN1’s Gene expression databases
Bgee ArrayExpress Genevestigator
XRN1’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.