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Mouse Ccdc88a (aa 1-1873 )
Ccdc88a Swiss - Prot #
Q5SNZ0
Ccdc88a Protein names
Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A)

(G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-

related protein 1) (HkRP1)
Ccdc88a Gene names
Ccdc88a Grdn Kiaa1212
Organism
Mus musculus (Mouse)
Ccdc88a Entry name
GRDN_MOUSE

Ccdc88a Codon-optimized cDNA Clone
Ccdc88a CDNA Cat#
RPY2645
Tag
cDNA Ccdc88a contains A 6x histidine tag
Condon optimized Ccdc88a cDNA Formulation
Liquid
Condon optimized Ccdc88a cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Ccdc88a cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Ccdc88a Protein
Recombinant Ccdc88a Protein Cat#
PY2645
Ccdc88a Protein Source
Recombinant protein
Recombinant Ccdc88a Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Ccdc88a Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Ccdc88a Protein Activity
N/A
Tag
Recombinant Ccdc88a contains A 6x histidine tag
Recombinant Ccdc88a protein Formulation
Liquid
Recombinant Ccdc88a protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Ccdc88aProtein or cDNA
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Ccdc88a’s Protein family
CCDC88 family
Ccdc88a’s Subcellular locations
Membrane. Cell membrane. Cytoplasm > cytosol. Cytoplasmic vesicle. Cell projection >

lamellipodium.
Ccdc88a’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Essential for the integrity of the actin cytoskeleton and for cell

migration. Required for formation of actin stress fibers and lamellipodia. May be

involved in membrane sorting in the early endosome (By similarity). Plays a role as

a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the

process of newborn neurons integration during adult neurogenesis, including

correct neuron positioning, dendritic development and synapse formation. Enhances

phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of

AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of

AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and

FOXO1/FKHR, and regulates DNA replication and cell proliferation.
Ccdc88a Sequence databases
EMBL DDBJ GenBank
Ccdc88a 3D structure databases
ModBase
Ccdc88a’s Protein-protein interaction databases
STRING
Ccdc88a’s Proteomic databases
PRIDE
Ccdc88a’s Genome annotation databases
Ensembl GeneID KEGG UCSC
Ccdc88a’s Organism-specific databases
CTD MGI
Ccdc88a’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Ccdc88a’s Gene expression databases
Bgee ArrayExpress Genevestigator
Ccdc88a’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.