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Mouse Dock3 (aa 1-2027 )
Dock3 Swiss - Prot #
Q8CIQ7
Dock3 Protein names
Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein)

(PBP)
Dock3 Gene names
Dock3 Moca
Organism
Mus musculus (Mouse)
Dock3 Entry name
DOCK3_MOUSE

Dock3 Codon-optimized cDNA Clone
Dock3 CDNA Cat#
RPY2683
Tag
cDNA Dock3 contains A 6x histidine tag
Condon optimized Dock3 cDNA Formulation
Liquid
Condon optimized Dock3 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Dock3 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Dock3 Protein
Recombinant Dock3 Protein Cat#
PY2683
Dock3 Protein Source
Recombinant protein
Recombinant Dock3 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Dock3 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Dock3 Protein Activity
N/A
Tag
Recombinant Dock3 contains A 6x histidine tag
Recombinant Dock3 protein Formulation
Liquid
Recombinant Dock3 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Dock3Protein or cDNA
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Dock3’s Protein family
DOCK family
Dock3’s Subcellular locations
Cytoplasm.
Dock3’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Potential guanine nucleotide exchange factor (GEF). GEF proteins

activate some small GTPases by exchanging bound GDP for free GTP. Its

interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT

phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic

expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein

and lowers the rate of cell-substratum adhesion, suggesting that it may affect the

function of some small GTPase involved in the regulation of actin cytoskeleton or

cell adhesion receptors.
Dock3 Sequence databases
EMBL DDBJ GenBank
Dock3 3D structure databases
ModBase
Dock3’s Protein-protein interaction databases
STRING
Dock3’s Proteomic databases
PRIDE
Dock3’s Genome annotation databases
Ensembl GeneID KEGG UCSC
Dock3’s Organism-specific databases
CTD MGI
Dock3’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Dock3’s Gene expression databases
Bgee ArrayExpress Genevestigator
Dock3’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.