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Mouse Rif1 (aa 1-2419 )
Rif1 Swiss - Prot #
Q6PR54
Rif1 Protein names
Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) (mRif1)
Rif1 Gene names
Rif1
Organism
Mus musculus (Mouse)
Rif1 Entry name
RIF1_MOUSE

Rif1 Codon-optimized cDNA Clone
Rif1 CDNA Cat#
RPY2741
Tag
cDNA Rif1 contains A 6x histidine tag
Condon optimized Rif1 cDNA Formulation
Liquid
Condon optimized Rif1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Rif1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Rif1 Protein
Recombinant Rif1 Protein Cat#
PY2741
Rif1 Protein Source
Recombinant protein
Recombinant Rif1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Rif1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Rif1 Protein Activity
N/A
Tag
Recombinant Rif1 contains A 6x histidine tag
Recombinant Rif1 protein Formulation
Liquid
Recombinant Rif1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Rif1Protein or cDNA
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Rif1’s Protein family
Rif1’s Subcellular locations
Nucleus. Chromosome > telomere. Cytoplasm > cytoskeleton > spindle.
Rif1’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Required for checkpoint mediated arrest of cell cycle progression in

response to DNA damage during S-phase (the intra-S-phase checkpoint). This

checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one

involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires

CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no

role in either the G1/S or G2/M DNA damage checkpoints (By similarity).
Rif1 Sequence databases
EMBL DDBJ GenBank
Rif1 3D structure databases
ModBase
Rif1’s Protein-protein interaction databases
STRING
Rif1’s Proteomic databases
PRIDE
Rif1’s Genome annotation databases
Ensembl GeneID KEGG UCSC
Rif1’s Organism-specific databases
CTD MGI
Rif1’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Rif1’s Gene expression databases
Bgee ArrayExpress Genevestigator
Rif1’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.