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Mouse Cenpe (aa 1-2474 )
Cenpe Swiss - Prot #
Q6RT24
Cenpe Protein names
Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin superfamily

protein 10) (KIF10) (Motor domain of KIF10)
Cenpe Gene names
Cenpe
Organism
Mus musculus (Mouse)
Cenpe Entry name
CENPE_MOUSE

Cenpe Codon-optimized cDNA Clone
Cenpe CDNA Cat#
RPY2754
Tag
cDNA Cenpe contains A 6x histidine tag
Condon optimized Cenpe cDNA Formulation
Liquid
Condon optimized Cenpe cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Cenpe cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cenpe Protein
Recombinant Cenpe Protein Cat#
PY2754
Cenpe Protein Source
Recombinant protein
Recombinant Cenpe Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Cenpe Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Cenpe Protein Activity
N/A
Tag
Recombinant Cenpe contains A 6x histidine tag
Recombinant Cenpe protein Formulation
Liquid
Recombinant Cenpe protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
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Cenpe’s Protein family
Kinesin-like protein family
Cenpe’s Subcellular locations
Cytoplasm > cytoskeleton > spindle. Chromosome > centromere > kinetochore.
Cenpe’s FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Essential for the maintenance of chromosomal stability through

efficient stabilization of microtubule capture at kinetochores. Plays a key role in the

movement of chromosomes toward the metaphase plate during mitosis. Is a slow

plus end-directed motor whose activity is essential for metaphase chromosome

alignment. Couples chromosome position to microtubule depolymerizing activity.

The highly processive microtubule-dependent motor activity of CENPE serves to

power chromosome congression and provides a flexible, motile tether linking

kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint

signal at individual kinetochores to prevent aneuploidy due to single chromosome

loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to

attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase

activity. Accumulates just before mitosis at the G2 phase of the cell cycle.
Cenpe Sequence databases
EMBL DDBJ GenBank
Cenpe 3D structure databases
ModBase
Cenpe’s Protein-protein interaction databases
STRING
Cenpe’s Proteomic databases
PRIDE
Cenpe’s Genome annotation databases
Ensembl GeneID KEGG UCSC
Cenpe’s Organism-specific databases
CTD MGI
Cenpe’s Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Cenpe’s Gene expression databases
Bgee ArrayExpress Genevestigator
Cenpe’s Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.