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HUMAN MAD2L2 (aa 1-211 )
MAD2L2 Swiss-Prot #
Q9UI95
MAD2L2 Protein names
Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2)

(MAD2-like protein 2) (REV7 homolog) (hREV7)
MAD2L2 Gene names
MAD2L2 MAD2B REV7
Organism
Homo sapiens (Human)
MAD2L2 Entry name
MD2L2_HUMAN

MAD2L2 Codon-optimized cDNA Clone
MAD2L2 CDNA Cat#
RPY0313
Tag
cDNA MAD2L2 contains A 6x histidine tag
Condon optimized MAD2L2 cDNA Formulation
Liquid
Condon optimized MAD2L2 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized MAD2L2 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag.

2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MAD2L2 Protein
Recombinant MAD2L2 Protein Cat#
PY0313
MAD2L2 Protein Source
Recombinant protein
Recombinant MAD2L2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant MAD2L2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant MAD2L2 Protein Activity
N/A
Tag
Recombinant MAD2L2 contains A 6x histidine tag
Recombinant MAD2L2 protein Formulation
Liquid
Recombinant MAD2L2 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
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MAD2L2 Protein family
MAD2L2 Subcellular locations
Nucleus. Cytoplasm > cytoskeleton > spindle. Cytoplasm.
MAD2L2 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Adapter protein able to interact with different proteins and involved in

different biological processes. Mediates the interaction between the error-prone

DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1,

thereby mediating the second polymerase switching in translesion DNA synthesis.

Translesion DNA synthesis releases the replication blockade of replicative

polymerases, stalled in presence of DNA lesions. May also regulate another aspect

of cellular response to DNA damage through regulation of the JNK-mediated

phosphorylation and activation of the transcriptional activator ELK1. Inhibits the

FZR1- and probably CDC20-mediated activation of the anaphase promoting

complex APC thereby regulating progression through the cell cycle. Regulates

TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal

transdifferentiation.
MAD2L2 Sequence databases
EMBL DDBJ GenBank
MAD2L2 3D structure databases
ModBase
MAD2L2 Protein-protein interaction databases
STRING
MAD2L2 Proteomic databases
PRIDE
MAD2L2 Genome annotation databases
Ensembl GeneID KEGG UCSC
MAD2L2 Organism-specific databases
CTD MGI
MAD2L2 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
MAD2L2 Gene expression databases
Bgee ArrayExpress Genevestigator
MAD2L2 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.