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MOUSE Ska1 (aa 1-254 )
Ska1 Swiss-Prot #
Q9CPV1
Ska1 Protein names
Spindle and kinetochore-associated protein 1
Ska1 Gene names
Ska1
Organism
Mus musculus (Mouse)
Ska1 Entry name
SKA1_MOUSE

Ska1 Codon-optimized cDNA Clone
Ska1 CDNA Cat#
RPY0405
Tag
cDNA Ska1 contains A 6x histidine tag
Condon optimized Ska1 cDNA Formulation
Liquid
Condon optimized Ska1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Ska1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag.

2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Ska1 Protein
Recombinant Ska1 Protein Cat#
PY0405
Ska1 Protein Source
Recombinant protein
Recombinant Ska1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Ska1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Ska1 Protein Activity
N/A
Tag
Recombinant Ska1 contains A 6x histidine tag
Recombinant Ska1 protein Formulation
Liquid
Recombinant Ska1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Ska1 Protein or cDNA
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Ska1 Protein family
SKA1 family
Ska1 Subcellular locations
Cytoplasm > cytoskeleton > spindle. Chromosome > centromere > kinetochore.
Ska1 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex

of the outer kinetochore that is essential for proper chromosome segregation.

Required for timely anaphase onset during mitosis, when chromosomes undergo

bipolar attachment on spindle microtubules leading to silencing of the spindle

checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule

interface and directly associates with microtubules as oligomeric assemblies. The

complex facilitates the processive movement of microspheres along a microtubule

in a depolymerization-coupled manner. In the complex, it mediates the interaction

with microtubules (By similarity).
Ska1 Sequence databases
EMBL DDBJ GenBank
Ska1 3D structure databases
ModBase
Ska1 Protein-protein interaction databases
STRING
Ska1 Proteomic databases
PRIDE
Ska1 Genome annotation databases
Ensembl GeneID KEGG UCSC
Ska1 Organism-specific databases
CTD MGI
Ska1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Ska1 Gene expression databases
Bgee ArrayExpress Genevestigator
Ska1 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.