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HUMAN PPP4C (aa 1-307 )
PPP4C Swiss-Prot #
P60510
PPP4C Protein names
Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein

phosphatase X) (PP-X)
PPP4C Gene names
PPP4C PPP4 PPX
Organism
Homo sapiens (Human)
PPP4C Entry name
PP4C_HUMAN

PPP4C Codon-optimized cDNA Clone
PPP4C CDNA Cat#
RPY0552
Tag
cDNA PPP4C contains A 6x histidine tag
Condon optimized PPP4C cDNA Formulation
Liquid
Condon optimized PPP4C cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized PPP4C cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2.

May be used as RNAi assistance to restore the loss-of-function.

Recombinant PPP4C Protein
Recombinant PPP4C Protein Cat#
PY0552
PPP4C Protein Source
Recombinant protein
Recombinant PPP4C Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant PPP4C Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant PPP4C Protein Activity
N/A
Tag
Recombinant PPP4C contains A 6x histidine tag
Recombinant PPP4C protein Formulation
Liquid
Recombinant PPP4C protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant PPP4C Protein or cDNA
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PPP4C Protein family
PPP phosphatase family, PP-4 (PP-X) subfamily
PPP4C Subcellular locations
Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome.
PPP4C FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Protein phosphatase that is involved in many processes such as

microtubule organization at centrosomes, maturation of spliceosomal snRNPs,

apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-

terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint

signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4

complex may play a role in dephosphorylation and regulation of HDAC3. The

PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX

phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication

and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1

phosphorylation sites and negatively regulates CDK1 activity in interphase (By

similarity).
PPP4C Sequence databases
EMBL DDBJ GenBank
PPP4C 3D structure databases
ModBase
PPP4C Protein-protein interaction databases
STRING
PPP4C Proteomic databases
PRIDE
PPP4C Genome annotation databases
Ensembl GeneID KEGG UCSC
PPP4C Organism-specific databases
CTD MGI
PPP4C Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
PPP4C Gene expression databases
Bgee ArrayExpress Genevestigator
PPP4C Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.