| PPP2CA Swiss-Prot # |
| P67775 |
| PPP2CA Protein names |
| Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC |
| 3.1.3.16) (Replication protein C) (RP-C) |
| Organism |
| Homo sapiens (Human) |
| PPP2CA Entry name |
| PP2AA_HUMAN |
| PPP2CA Codon-optimized cDNA Clone |
| Tag |
| cDNA PPP2CA contains A 6x histidine tag |
| Condon optimized PPP2CA cDNA Formulation |
| Liquid |
| Condon optimized PPP2CA cDNA Storage |
| −20℃ to −70℃. Avoid repeated freeze-thaw cycles. |
| Condon optimized PPP2CA cDNA Application (s) |
| Applications: 1. Codon-optimized cDNA sequence designed for |
| recombinant protein production in both E.coli and Mammalian cell. The |
| cDNA has been cloned into E.coli expression vector with 6x Histidine tag. 2. |
| May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant PPP2CA Protein |
| Recombinant PPP2CA Protein Cat# |
| PY0558 |
| PPP2CA Protein Source |
| Recombinant protein |
| Recombinant PPP2CA Protein Applications |
| Western Blot, may be used for other applications determined by user |
| Recombinant PPP2CA Protein Purity |
| >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant PPP2CA Protein Activity |
| N/A |
| Tag |
| Recombinant PPP2CA contains A 6x histidine tag |
| Recombinant PPP2CA protein Formulation |
| Liquid |
| Recombinant PPP2CA protein Storage |
| −20℃ to −70℃. Avoid repeated freeze-thaw cycles. |
| PPP2CA Protein family |
| PPP phosphatase family, PP-1 subfamily |
| PPP2CA Subcellular locations |
| Cytoplasm. Nucleus. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle pole. |
| PPP2CA FUNCTION (According to UniProtKB/Swiss-Prot) |
| FUNCTION: PP2A can modulate the activity of phosphorylase B kinase casein |
| kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with |
| SGOL2 to protect centromeric cohesin from separase-mediated cleavage in |
| oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 |
| large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, |
| preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit |
| was most active, followed by the AC form, which was more active than the ABC form, |
| and activity of all three forms was strongly stimulated by manganese, and to a |
| lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC |
| form is inhibited by small T antigen. |
| PPP2CA 3D structure databases |
| ModBase |
| PPP2CA Protein-protein interaction databases |
| STRING |
| PPP2CA Proteomic databases |
| PRIDE |
| PPP2CA Organism-specific databases |
| CTD |
MGI |
| FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS. |
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