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MOUSE Mlst8 (aa 1-326 )
Mlst8 Swiss-Prot #
Q9DCJ1
Mlst8 Protein names
Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-

like) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8)
Mlst8 Gene names
Mlst8 Gbl Lst8
Organism
Mus musculus (Mouse)
Mlst8 Entry name
LST8_MOUSE

Mlst8 Codon-optimized cDNA Clone
Mlst8 CDNA Cat#
RPY0603
Tag
cDNA Mlst8 contains A 6x histidine tag
Condon optimized Mlst8 cDNA Formulation
Liquid
Condon optimized Mlst8 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Mlst8 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag.

2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Mlst8 Protein
Recombinant Mlst8 Protein Cat#
PY0603
Mlst8 Protein Source
Recombinant protein
Recombinant Mlst8 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Mlst8 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Mlst8 Protein Activity
N/A
Tag
Recombinant Mlst8 contains A 6x histidine tag
Recombinant Mlst8 protein Formulation
Liquid
Recombinant Mlst8 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Mlst8 Protein or cDNA
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Mlst8 Protein family
WD repeat LST8 family
Mlst8 Subcellular locations
Cytoplasm.
Mlst8 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Subunit of both mTORC1 and mTORC2, which regulates cell growth

and survival in response to nutrient and hormonal signals. mTORC1 is activated in

response to growth factors or amino-acids. Growth factor-stimulated mTORC1

activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to

the activation of the RHEB GTPase that potently activates the protein kinase activity

of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the

lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated

mTORC1 up-regulates protein synthesis by phosphorylating key regulators of

mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1

and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1

phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein

synthesis by phosphorylating PDCD4 and targeting it for degradation. Within

mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In

nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors

RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth

factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream

of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or

more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the

serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role

in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the

activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full

activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2

also modulates the phosphorylation of PRKCA on 'Ser-657'.
Mlst8 Sequence databases
EMBL DDBJ GenBank
Mlst8 3D structure databases
ModBase
Mlst8 Protein-protein interaction databases
STRING
Mlst8 Proteomic databases
PRIDE
Mlst8 Genome annotation databases
Ensembl GeneID KEGG UCSC
Mlst8 Organism-specific databases
CTD MGI
Mlst8 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Mlst8 Gene expression databases
Bgee ArrayExpress Genevestigator
Mlst8 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.