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RAT Prr5 (aa 1-387 )
Prr5 Swiss-Prot #
Q5FVG6
Prr5 Protein names
Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1)
Prr5 Gene names
Prr5 Protor1
Organism
Rattus norvegicus (Rat)
Prr5 Entry name
PRR5_RAT

Prr5 Codon-optimized cDNA Clone
Prr5 CDNA Cat#
RPY0825
Tag
cDNA Prr5 contains A 6x histidine tag
Condon optimized Prr5 cDNA Formulation
Liquid
Condon optimized Prr5 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Prr5 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag.

2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Prr5 Protein
Recombinant Prr5 Protein Cat#
PY0825
Prr5 Protein Source
Recombinant protein
Recombinant Prr5 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Prr5 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Prr5 Protein Activity
N/A
Tag
Recombinant Prr5 contains A 6x histidine tag
Recombinant Prr5 protein Formulation
Liquid
Recombinant Prr5 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Prr5 Protein or cDNA
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Prr5 Protein family
PROTOR family
Prr5 Subcellular locations
Prr5 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in

response to hormonal signals. mTORC2 is activated by growth factors, but, in

contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function

upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating

one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes

the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical

role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of

the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full

activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-421'. mTORC2

also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an

important role in regulation of PDGFRB expression and in modulation of platelet-

derived growth factor signaling. May act as a tumor suppressor in breast cancer

(By similarity).
Prr5 Sequence databases
EMBL DDBJ GenBank
Prr5 3D structure databases
ModBase
Prr5 Protein-protein interaction databases
STRING
Prr5 Proteomic databases
PRIDE
Prr5 Genome annotation databases
Ensembl GeneID KEGG UCSC
Prr5 Organism-specific databases
CTD MGI
Prr5 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Prr5 Gene expression databases
Bgee ArrayExpress Genevestigator
Prr5 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.